Introduction

Wound healing disturbances as possible side effects of calcitonin gene-related peptide (CGRP) antibody treatment have been discussed previously but not yet described in humans. Basic research suggests that calcitonin gene-related peptide plays an important role in keratinocyte migration, vascularization and immune response and lack of calcitonin gene-related peptide may lead to impaired wound healing.

Case

A 51-year-old female migraine patient was treated with the CGRP receptor antibody erenumab for 6 months, which led to a relevant reduction of migraine days. During the treatment, two periods of severely impaired wound healing occurred after a trivial skin injury without spatial relation to the injection site. Skin biopsy confirmed a deep perivascular and interstitial lymphohistiocytic infiltrate with admixed eosinophils, ulceration of the epithelium, a heavy edema of the papillary dermis and focally thrombosed vessels.

Conclusion

Impaired wound healing might be relevant side effects of CGRP antibody therapy and anamnesis within the course of treatment should also include possible observation of impaired wound healing or planned surgery.

中文翻译：

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降钙素基因相关肽受体抗体治疗可能产生的副作用导致偏头痛患者伤口愈合受损：病例报告。

介绍

伤口愈合障碍作为降钙素基因相关肽 (CGRP) 抗体治疗的可能副作用之前已经讨论过，但尚未在人类中进行描述。基础研究表明，降钙素基因相关肽在角质形成细胞迁移、血管形成和免疫反应中起着重要作用，缺乏降钙素基因相关肽可能会导致伤口愈合受损。

案件

一名 51 岁女性偏头痛患者接受 CGRP 受体抗体 erenumab 治疗 6 个月，导致偏头痛天数相应减少。在治疗期间，在与注射部位没有空间关系的轻微皮肤损伤后发生了两个严重受损的伤口愈合期。皮肤活检证实深部血管周围和间质淋巴组织细胞浸润与混合嗜酸性粒细胞、上皮溃疡、真皮乳头状严重水肿和局部血栓形成的血管。

结论

伤口愈合受损可能是 CGRP 抗体治疗的相关副作用，治疗过程中的病史还应包括可能观察到伤口愈合受损或计划手术。