Metabolomics Study Revealing the Potential Risk and Predictive Value of Fragmented QRS for Acute Myocardial Infarction.,Journal of Proteome Research

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Metabolomics Study Revealing the Potential Risk and Predictive Value of Fragmented QRS for Acute Myocardial Infarction.
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2020-06-14 , DOI: 10.1021/acs.jproteome.0c00247
Jiankang Li ₁ , Wenting Duan ₂ , Lin Wang ₃ , Yiqing Lu ₂ , Zhaozhao Shi ₂ , Tingli Lu ₄

Affiliation

Patients with nonobstructive coronary artery disease (NOCAD) have high risk associated with acute myocardial infarction (AMI), and fragmented QRS (fQRS) has a predictive value of AMI after percutaneous coronary intervention (PCI). A cohort of 254 participants were recruited including 136 NOCAD and 118 AMI patients from Xi’an No. 1 Hospital. Comprehensive metabolomics was performed by UPLC-Q/TOF-MS with multivariate statistical analyses. Hazard ratios were measured to discriminate the prognostic in AMI after PCI between differential metabolites and fQRS. OPLS-DA separated metabolites from NOCAD and AMI in serum. A total of 23 differential metabolites were identified between NOCAD and AMI. In addition, four differential metabolites, namely, acetylglycine, threoninyl-glycine, glutarylglycine, and nonanoylcarnitine, were identified between fQRS and non-fQRS in AMI. The hazard ratios demonstrate that the metabolites were associated with the risk of cardiac death, recurrent angina, readmissions, and major adverse cardiovascular events, which may clarify the mechanism of fQRS as a predictor in the prognostic of AMI after PCI. This study identified novel differential metabolites to distinguish the difference from NOCAD to AMI and clarify the mechanism of fQRS in prognostic of AMI after PCI, which may provide novel insights into potential risks and prognostic of AMI.

中文翻译：

代谢组学研究揭示了碎裂QRS对急性心肌梗死的潜在风险和预测价值。

非阻塞性冠状动脉疾病（NOCAD）的患者与急性心肌梗塞（AMI）相关，并且经皮冠状动脉介入治疗（PCI）后碎片QRS（fQRS）具有AMI的预测价值。招募了254名参与者，其中136名NOCAD和118名AMI患者来自西安市第一医院。通过UPLC-Q / TOF-MS进行综合代谢组学，并进行多变量统计分析。测量危险比以区分PCI后差异代谢物和fQRS之间的预后。OPLS-DA从血清中的NOCAD和AMI中分离出代谢物。在NOCAD和AMI之间共鉴定出23种差异代谢物。此外，还有四种不同的代谢产物，即乙酰基甘氨酸，苏氨酸-甘氨酸，戊二酰甘氨酸和壬酰基肉碱，在AMI中的fQRS和非fQRS之间被识别。危险比表明，代谢物与心脏死亡，复发性心绞痛，再入院和重大不良心血管事件的风险相关，这可能阐明了fQRS作为PCI后AMI预后的预测因子的机制。本研究确定了新的差异代谢物，以区分从NOCAD到AMI的差异，并阐明fQRS在PCI后AMI预后中的作用机制，这可能为AMI的潜在风险和预后提供新的见解。

更新日期：2020-08-08

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