Cyclodextrin (CD) nanofibers have recently emerged as high-performance materials owing to their large surface area-to-volume ratio, along with the presence of high active CD content for their applications in drug delivery and water treatment. Even though there are several studies on the polymer-free electrospinning of CD molecules of different types, the effects of electrospinning process parameters on the morphology and diameter of the resultant fibers have not addressed yet. In this study, the influence of electrospinning process variables on the morphology and diameter of the resultant CD nanofibers is systematically studied using two different solvent systems, i.e., water and N, N-dimethylformamide (DMF). On adjusting the electrospinning process parameters (i.e., electrical field, flow rate, tip-to-collector distance (TCD), and needle diameter), uniform CD nanofibers could be produced from aqueous and DMF solutions. Generally, the electrospinning of thicker fibers was observed by increasing the applied voltage and flow rate due to higher mass flow. Increasing TCD boosted the fiber diameter. Likewise, the use of needles with larger diameters resulted in the electrospinning of thicker fibers from DMF solutions, which might be attributed to higher viscosity due to reduced shear rate.

中文翻译：

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环糊精纳米纤维的静电纺丝：工艺参数的影响

环糊精（CD）纳米纤维由于其大的表面积/体积比以及高活性CD含量的存在，最近已成为高性能材料，可用于药物输送和水处理。即使对不同类型的CD分子进行无聚合物静电纺丝有一些研究，但静电纺丝工艺参数对所得纤维的形态和直径的影响尚未解决。在这项研究中，使用两种不同的溶剂系统，即水和N，N-二甲基甲酰胺（DMF），系统地研究了静电纺丝工艺变量对所得CD纳米纤维的形态和直径的影响。在调整静电纺丝工艺参数（即电场，流速，针尖到收集器的距离（TCD））时，和针直径），可以从水溶液和DMF溶液中生产出均匀的CD纳米纤维。通常，由于较高的质量流量，通过增加施加的电压和流速来观察较粗纤维的静电纺丝。TCD的增加会增加纤维直径。同样，使用大直径的针会导致从DMF溶液中纺出较粗的纤维，这可能是由于剪切速率降低而导致的较高粘度。