ABSTRACT

Introduction

Helicobacter pylori

causes, via the influence of several virulence factors, persistent infection of the stomach, which leads to severe complications. Vacuolating cytotoxin A (VacA) is observed in almost all clinical strains of H. pylori; however, only some strains produce the toxigenic and pathogenic VacA, which is influenced by the gene sequence variations. VacA exerts its action by causing cell vacuolation and apoptosis. We performed a PubMed search to review the latest literatures published in English language.

Areas covered

Articles regarding H. pylori VacA and its genotypes, architecture, internalization, and role in gastric infection and pathogenicity are reviewed. We included the search for recently published literature until January 2020.

Expert opinion

H. pylori

VacA plays a crucial role in severe gastric pathogenicity. In addition, VacA mediated in vivo bacterial survival leads to persistent infection and an enhanced bacterial evasion from the action of antibiotics and the innate host defense system, which leads to drug evasion. VacA as a co-stimulator for the CagA phosphorylation may exert a synergistic effect playing an important role in the CagA-mediated pathogenicity.

中文翻译：

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空泡细胞毒素A在幽门螺杆菌感染中的作用及其对胃病发病机制的影响。

摘要

介绍

幽门螺杆菌

通过多种毒力因素的影响，导致胃的持续感染，从而导致严重的并发症。在几乎所有的幽门螺杆菌临床菌株中均观察到空泡的细胞毒素A（VacA）；然而，只有一些菌株产生产毒和致病性的VacA，这受基因序列变异的影响。VacA通过引起细胞空泡化和凋亡而发挥作用。我们进行了PubMed搜索，以回顾用英语发表的最新文献。

覆盖区域

本文对有关幽门螺杆菌VacA及其基因型，结构，内在化及其在胃感染和致病性中的作用的文章进行了综述。我们搜索了直到2020年1月的最新出版文献。

专家意见

幽门螺杆菌

VacA在严重的胃病致病性中起关键作用。此外，VacA介导的体内细菌存活导致持久性感染，以及由于抗生素和先天宿主防御系统的作用而增强的细菌逃逸，从而导致药物逃逸。VacA作为CagA磷酸化的共同刺激剂可能发挥协同作用，在CagA介导的致病性中起重要作用。