Abstract The aims of this study were to investigate the effect of hepatic sympathetic nerve removal on glucose and lipid metabolism in rats with cognitive impairment and to evaluate the relationship between these effects and liver Glut2 expression. Hippocampal injection of Aβ1–42 was used to induce cognitive impairment. Impaired rats were divided into experimental, sham, and control groups. The experimental group was injected with 6-hydroxydopamine to remove the sympathetic nerve. At 4 weeks post injection, body weight, food and water intake, blood sugar, and blood lipids were measured, and periodic acid-Schiff (PAS) staining was used to assess the liver glycogen content. Liver Glut2 mRNA and protein were also detected. The experimental group showed reduced body weight, food intake, and blood glucose levels and elevated insulin levels compared with the control group. PAS staining showed higher glycogen contents in the experimental group than in controls. The expression levels of Glut2 mRNA and protein in the experimental group were significantly lower than in the controls. Metabolism was significantly impacted in rats with cognitive impairment following removal of the hepatic sympathetic nerve. Disruption to Glut2 liver expression via sympathetic nerve disruption represents a possible underlying mechanism.

中文翻译：

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肝交感神经切除对认知障碍动物模型能量代谢的影响及其与Glut2表达的关系

摘要 本研究的目的是研究去除肝交感神经对认知障碍大鼠糖脂代谢的影响，并评估这些影响与肝脏 Glut2 表达之间的关系。海马注射 Aβ1-42 用于诱导认知障碍。将受损大鼠分为实验组、假手术组和对照组。实验组注射6-羟基多巴胺切除交感神经。在注射后 4 周，测量体重、食物和水的摄入量、血糖和血脂，并使用高碘酸-希夫 (PAS) 染色评估肝糖原含量。肝脏 Glut2 mRNA 和蛋白质也被检测到。实验组表现出体重减少、食物摄入量减少、与对照组相比，血糖水平和胰岛素水平升高。PAS 染色显示实验组的糖原含量高于对照组。实验组Glut2 mRNA和蛋白的表达水平显着低于对照组。去除肝交感神经后，认知障碍大鼠的代谢受到显着影响。通过交感神经中断对 Glut2 肝脏表达的中断代表了一种可能的潜在机制。去除肝交感神经后，认知障碍大鼠的代谢受到显着影响。通过交感神经中断对 Glut2 肝脏表达的中断代表了一种可能的潜在机制。去除肝交感神经后，认知障碍大鼠的代谢受到显着影响。通过交感神经中断对 Glut2 肝脏表达的中断代表了一种可能的潜在机制。