当前位置: X-MOL 学术Photochem. Photobiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effect of Nail Thickness on Visible Radiation Transmittance: Implications for New Photodynamic Therapy Technologies in Onychomycosis
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2020-07-31 , DOI: 10.1111/php.13296
Enrique Navarrete- de Gálvez 1 , José Aguilera 2 , María Victoria de Gálvez 2 , Pablo Fonda-Pascual 3 , Enrique Herrera-Ceballos 2 , Alfonso Gago-Calderón 1
Affiliation  

Photodynamic therapy is taking importance as a nonintrusive treatment for nail onychomycosis. Knowledge of true transmittance values across nails could lead to qualitative and quantitative improvements in light‐based treatments. We have characterized the spectral transmittance of healthy and fungally infected human fingernails and toenails according to nail thickness, and we propose a surface transmittance model for the small‐scale optimization of light‐based treatments. Transmittance of fingernails and toenails was analyzed by means of spectroradiometric measurements under solar‐simulated visible light radiation (400 nm to 750 nm). The nail thickness was measured by means of microscope measurement. Transmittance was highest at longer wavelengths and decreased gradually as the wavelengths became shorter but with a significant nail transmittance of around 20% in the blue region of the spectrum. In the case of nails affected by onychomycosis, transmittance fell to under 10% because of the thickness of the nails, with no changes in spectral characteristics of transmitted light. Nail thickness is the main variable controlling exponentially light transmission in the visible spectrum and not only red radiation is effective for nail onychomycosis PDT. Blue light, the spectral band more effective for PPIX absorption is also effectively transmitted.

中文翻译:

指甲厚度对可见辐射透射率的影响:对新光动力治疗技术在甲真菌病中的影响

光动力疗法作为一种非侵入性治疗指甲真菌病的方法越来越重要。了解整个指甲的真实透射率值可能会导致基于光的治疗的定性和定量改进。我们根据指甲厚度表征了健康和受真菌感染的人类手指甲和脚趾甲的光谱透射率,并提出了一个表面透射率模型,用于光基治疗的小规模优化。通过在太阳模拟可见光辐射(400 nm 至 750 nm)下的光谱辐射测量来分析手指甲和脚趾甲的透射率。通过显微镜测量来测量指甲厚度。透射率在较长波长时最高,随着波长变短而逐渐降低,但在光谱的蓝色区域具有约 20% 的显着指甲透射率。对于受甲真菌病影响的指甲,由于指甲的厚度,透射率下降到 10% 以下,而透射光的光谱特性没有变化。指甲厚度是控制可见光谱中指数光透射的主要变量,不仅红色辐射对指甲甲真菌病 PDT 有效。蓝光,对 PPIX 吸收更有效的光谱带也被有效透射。透射光的光谱特性没有变化。指甲厚度是控制可见光谱中指数光透射的主要变量,不仅红色辐射对指甲甲真菌病 PDT 有效。蓝光,对 PPIX 吸收更有效的光谱带也被有效透射。透射光的光谱特性没有变化。指甲厚度是控制可见光谱中指数光透射的主要变量,不仅红色辐射对指甲甲真菌病 PDT 有效。蓝光,对 PPIX 吸收更有效的光谱带也被有效透射。
更新日期:2020-07-31
down
wechat
bug