当前位置：
X-MOL 学术
›
FEBS Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The role of sphingolipids in endoplasmic reticulum stress
FEBS Letters ( IF 3.0 ) Pub Date : 2020-06-28 , DOI: 10.1002/1873-3468.13863 Woo-Jae Park 1 , Joo-Won Park 2
FEBS Letters ( IF 3.0 ) Pub Date : 2020-06-28 , DOI: 10.1002/1873-3468.13863 Woo-Jae Park 1 , Joo-Won Park 2
Affiliation
|
The endoplasmic reticulum (ER) is an important intracellular compartment in eukaryotic cells and has diverse functions, including protein synthesis, protein folding, lipid metabolism and calcium homeostasis. ER functions are disrupted by various intracellular and extracellular stimuli that cause ER stress, including the inhibition of glycosylation, disulphide bond reduction, ER calcium store depletion, impaired protein transport to the Golgi, excessive ER protein synthesis, impairment of ER‐associated protein degradation and mutated ER protein expression. Distinct ER stress signalling pathways, which are known as the unfolded protein response, are deployed to maintain ER homeostasis, and a failure to reverse ER stress triggers cell death. Sphingolipids are lipids that are structurally characterized by long‐chain bases, including sphingosine or dihydrosphingosine (also known as sphinganine). Sphingolipids are bioactive molecules long known to regulate various cellular processes, including cell proliferation, migration, apoptosis and cell–cell interaction. Recent studies have uncovered that specific sphingolipids are involved in ER stress. This review summarizes the roles of sphingolipids in ER stress and human diseases in the context of pathogenic events.
中文翻译：
鞘脂在内质网应激中的作用
内质网 (ER) 是真核细胞中重要的细胞内区室，具有多种功能，包括蛋白质合成、蛋白质折叠、脂质代谢和钙稳态。ER 功能被引起 ER 应激的各种细胞内和细胞外刺激破坏，包括糖基化抑制、二硫键还原、ER 钙库耗竭、蛋白质向高尔基体转运受损、ER 蛋白质合成过多、ER 相关蛋白质降解受损和ER 蛋白表达突变。不同的内质网应激信号通路，即未折叠蛋白反应，被用来维持内质网稳态，如果不能逆转内质网应激，则会触发细胞死亡。鞘脂是结构上以长链碱基为特征的脂质，包括鞘氨醇或二氢鞘氨醇（也称为鞘氨醇）。鞘脂是众所周知的生物活性分子，可以调节各种细胞过程，包括细胞增殖、迁移、凋亡和细胞间相互作用。最近的研究发现，特定的鞘脂与内质网应激有关。本综述总结了鞘脂在致病事件背景下在内质网应激和人类疾病中的作用。
更新日期：2020-06-28
中文翻译：
鞘脂在内质网应激中的作用
内质网 (ER) 是真核细胞中重要的细胞内区室，具有多种功能，包括蛋白质合成、蛋白质折叠、脂质代谢和钙稳态。ER 功能被引起 ER 应激的各种细胞内和细胞外刺激破坏，包括糖基化抑制、二硫键还原、ER 钙库耗竭、蛋白质向高尔基体转运受损、ER 蛋白质合成过多、ER 相关蛋白质降解受损和ER 蛋白表达突变。不同的内质网应激信号通路，即未折叠蛋白反应，被用来维持内质网稳态，如果不能逆转内质网应激，则会触发细胞死亡。鞘脂是结构上以长链碱基为特征的脂质，包括鞘氨醇或二氢鞘氨醇（也称为鞘氨醇）。鞘脂是众所周知的生物活性分子，可以调节各种细胞过程，包括细胞增殖、迁移、凋亡和细胞间相互作用。最近的研究发现，特定的鞘脂与内质网应激有关。本综述总结了鞘脂在致病事件背景下在内质网应激和人类疾病中的作用。
京公网安备 11010802027423号