Elevated KLF7 levels may serve as a prognosis signature and might contribute to progression of squamous carcinoma.,FEBS Open Bio

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Elevated KLF7 levels may serve as a prognosis signature and might contribute to progression of squamous carcinoma.
FEBS Open Bio ( IF 2.8 ) Pub Date : 2020-07-13 , DOI: 10.1002/2211-5463.12912
Jingrun Yang ₁ , Kuixia Xie ₂ , Zihui Wang ₃ , Chengxin Li ₁

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Global efforts have been undertaken to define the genome‐wide distribution of epigenetic markers in cancerous tissues, which provide an invaluable opportunity to understand cancer biology and identify predictive signatures. Several studies have focused on the gene expression patterns of squamous carcinoma to identify tumor subtypes and find prognostic and therapeutic targets because squamous carcinoma genomes showed high instability. However, the number of reliable reports referring prognostic significance of genes and their role in squamous carcinoma is still quite limited. Krüppel‐like factor 7 (KLF7) is a transcription factor that is widely expressed in numerous human tissues at low levels. Members of the KLF family have established roles in tumor cell fate, stress response, cell survival and the tumor‐initiating properties of cancer stem‐like cells. Hence to investigate whether KFL7 expression from cancer tissue holds promise as a prognostic and/or therapeutic target, we analyzed gene expression profiles from squamous carcinoma and surgical margin tissues in The Cancer Genome Atlas. We identified significant up‐regulation of KLF7 in squamous carcinoma, which was confirmed by immunohistochemical staining. Elevated KLF7 expression was associated with poor squamous carcinoma prognosis before and after correcting for confounding factors by multivariate Cox regression analysis. Several pathways, such as Neurotrophin and GnRH pathways, were activated in KLF7‐up‐regulated squamous carcinoma samples through Gene Set Enrichment Analysis. In conclusion, we consolidate the potential role(s) of KLF7 in squamous carcinoma carcinogenesis from The Cancer Genome Atlas surgical margin tissue, offering insights into expression signatures that are potentially useful for prognosis modalities.

中文翻译：

KLF7 水平升高可能作为预后标志，并可能导致鳞状癌的进展。

全球范围内都在努力定义癌组织中表观遗传标记的全基因组分布，这为了解癌症生物学和识别预测特征提供了宝贵的机会。由于鳞状癌基因组表现出高度不稳定性，一些研究重点关注鳞状癌的基因表达模式，以识别肿瘤亚型并寻找预后和治疗靶点。然而，涉及基因预后意义及其在鳞状癌中的作用的可靠报告数量仍然相当有限。 Krüppel 样因子 7 (KLF7) 是一种转录因子，在许多人体组织中低水平广泛表达。 KLF 家族成员已在肿瘤细胞命运、应激反应、细胞存活和癌症干细胞样细胞的肿瘤启动特性中发挥作用。因此，为了研究癌症组织中的KFL7表达是否有望作为预后和/或治疗靶标，我们分析了癌症基因组图谱中鳞状癌和手术边缘组织的基因表达谱。我们发现鳞状细胞癌中KLF7显着上调，并通过免疫组织化学染色证实。通过多变量 Cox 回归分析校正混杂因素之前和之后， KLF7表达升高与鳞状癌预后不良相关。通过基因集富集分析， KLF7上调的鳞状细胞癌样本中激活了多种途径，例如神经营养素和 GnRH 途径。总之，我们从癌症基因组图谱手术切缘组织中巩固了KLF7在鳞状细胞癌发生中的潜在作用，提供了对可能对预后模式有用的表达特征的见解。

更新日期：2020-07-13

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