Antibacterial and leishmanicidal activities of Syzygium aromaticum essential oil versus its major ingredient, eugenol,Flavour and Fragrance Journal

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Antibacterial and leishmanicidal activities of Syzygium aromaticum essential oil versus its major ingredient, eugenol
Flavour and Fragrance Journal ( IF 2.1 ) Pub Date : 2020-06-14 , DOI: 10.1002/ffj.3595
Mohammad Djaefar Moemenbellah‐Fard ₁ , Abbas Abdollahi ₂ , Ali Ghanbariasad ₃ , Mahmoud Osanloo _{4,

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Affiliation

The essential oil of Syzygium aromaticum (clove EO) and its major ingredients, eugenol, possess many biological activities such as antibacterial, antifungal, and antioxidant properties. Therefore, they have been widely used in traditional and contemporary medicine. In this study, the ingredients of clove EO were identified using GC‐MS analysis. The antibacterial and leishmanicidal activities of the total essential oil and eugenol were also investigated. Eugenol (65.41%), trans‐caryophyllene (12.6%), eugenol acetate (9.85%), caryophyllene oxide (3.00%), and α‐humulene (1.73%) were identified as five major components of clove EO. Additionally, the obtained IC₅₀s of clove EO, 177.66, 300.53, 362.94, and 248.08 μg/mL, against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, respectively, were lower than those of eugenol with IC₅₀s of 320.80, 692.91, 591.82, and 445.87 μg/mL. However, this difference was not significant, except against E coli. Also, clove EO and eugenol showed proper leishmanicidal effects on promastigotes of Leishmania tropica (180.24 and 233.52 μg/mL) and Leishmania major (654.76 and 517.14 μg/mL). Furthermore, there was no significant statistical difference between the anti‐Leishmania effect of EO and eugenol. Clove EO and eugenol showed proper antibacterial and leishmanicidal activities. However, the use of clove EO is preferable than eugenol because of the lower cost and straightforward preparation process.

中文翻译：

蒲桃精油的抑菌和杀菌作用与其主要成分丁子香酚

香蒲（丁香EO）及其主要成分丁子香酚的精油具有许多生物活性，例如抗菌，抗真菌和抗氧化特性。因此，它们已被广泛用于传统和现代医学中。在本研究中，使用GC-MS分析鉴定了丁香EO的成分。还研究了总精油和丁子香酚的抗菌和杀菌作用。丁香油的五个主要成分是丁香酚（65.41％），反式鬼臼烯（12.6％），乙酸丁子香酚（9.85％），石竹烯氧化物（3.00％）和α-hu草烯（1.73％）。此外，获得的丁香EO对金黄色葡萄球菌的IC ₅₀ s为177.66、300.53、362.94和248.08μg/ mL，大肠杆菌，铜绿假单胞菌和肺炎克雷伯菌均低于丁子香酚，IC ₅₀值为320.80、692.91、591.82和445.87μg/ mL。但是，除了针对大肠杆菌外，这种差异并不明显。此外，丁香EO和丁子香酚对热带利什曼原虫（180.24和233.52μg/ mL）和主要利什曼原虫（654.76和517.14μg/ mL）的前鞭毛体显示出适当的利什曼杀菌作用。此外，抗利什曼原虫之间无显着统计学差异EO和丁子香酚的作用。丁香油EO和丁子香酚显示出适当的抗菌和利什曼杀菌作用。但是，由于成本较低且制备过程简单，因此使用丁香EO比丁子香酚更好。

更新日期：2020-06-14

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