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Evaluation of Cell‐Penetrating Peptides Using Microfluidic In Vitro 3D Brain Endothelial Barrier
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-06-15 , DOI: 10.1002/mabi.202070011
Bohye Chung , Jaehoon Kim , Jiyoung Nam , Hyunho Kim , Yeju Jeong , Hui‐wen Liu , Youngkyu Cho , Yong Ho Kim , Hyun Jeong Oh , Seok Chung

Front Cover: In article number 1900425, Hyun Jeong Oh, Seok Chung and co‐workers reconstituted the 3D brain endothelial barrier in a microfluidic device with a hydrogel scaffold. The developed platform provides quantitative evaluation of the efficacy of cell‐penetrating peptide (CPP) utilizing receptor‐mediated transcytosis by various assays. The specific/non‐specific transcytosis of CPP in the microfluidic platform is demonstrated and evaluated.
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中文翻译:

使用微流体体外3D脑血管内皮屏障评估细胞穿透肽

封面:在第1900425号文章中,许贞正,徐重and及其同事在带有水凝胶支架的微流体装置中重建了3D脑内皮屏障。开发的平台通过各种测定方法,利用受体介导的胞吞作用,定量评估细胞穿透肽(CPP)的功效。证明和评估了CPP在微流体平台上的特异性/非特异性胞吞作用。
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更新日期:2020-06-15
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