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Engineering Mono-Chalcogen Nanomaterials for Omnipotent Anticancer Applications: Progress and Challenges.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-14 , DOI: 10.1002/adhm.202000273 Chenyang Xing 1 , Peng Yin 1 , Zhengchun Peng 1 , Han Zhang 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-14 , DOI: 10.1002/adhm.202000273 Chenyang Xing 1 , Peng Yin 1 , Zhengchun Peng 1 , Han Zhang 1
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Belonging to the chalcogen group, the elements selenium (Se) and tellurium (Te) are located in Group VI‐A of the periodic table. Zero‐valent nanodimensioned Se (nano‐Se) and Te (nano‐Te) have displayed important biomedical applications in recent years. The past two decades have witnessed an explosion in novel cancer treatment strategies using nano‐Se and nano‐Te as aggressive weapons against tumors. Indeed, they are both inorganic nanomedicines that suppress tumor cell proliferation, diffusion, and metastasis. Abundant synthesis strategies for rational and precise surface decoration of nano‐Se and nano‐Te make them significant players in resisting cancers by means of powerful multi‐modal treatment methods. This review focuses on the design and engineering of nano‐Se‐ and nano‐Te‐based nanodelivery systems and their precise uses in cancer treatment. The corresponding anticancer molecular mechanisms of nano‐Se and nano‐Te are discussed in detail. Given their different photo‐induced behaviors, the presence or absence of near infrared illumination is used as a defining characteristic when describing the anticancer applications of nano‐Se and nano‐Te. Finally, the challenges and future prospects of nano‐Se and nano‐Te are summarized and highlighted.
中文翻译：
工程用于全能抗癌的单硫族元素纳米材料：进展和挑战。
属于硫族元素的元素硒（Se）和碲（Te）位于元素周期表的VI-A组。近年来，零价纳米尺寸的Se（nano-Se）和Te（nano-Te）表现出重要的生物医学应用。在过去的二十年中，使用纳米硒和纳米碲作为对抗肿瘤的攻击性武器的新型癌症治疗策略出现了爆炸式增长。实际上，它们都是抑制肿瘤细胞增殖，扩散和转移的无机纳米药物。合理的，精确的纳米硒和纳米碲表面装饰的丰富合成策略使它们成为强大的多模式治疗方法中抵抗癌症的重要参与者。这篇综述主要关注基于纳米硒和纳米碲的纳米传递系统的设计和工程及其在癌症治疗中的精确用途。详细讨论了纳米硒和纳米碲的相应抗癌分子机制。考虑到它们的光诱导行为不同，在描述nano-Se和nano-Te的抗癌应用时，将近红外照明的存在与否作为定义特征。最后，总结并强调了纳米硒和纳米碲的挑战和未来前景。
更新日期：2020-07-22
中文翻译：
工程用于全能抗癌的单硫族元素纳米材料：进展和挑战。
属于硫族元素的元素硒（Se）和碲（Te）位于元素周期表的VI-A组。近年来，零价纳米尺寸的Se（nano-Se）和Te（nano-Te）表现出重要的生物医学应用。在过去的二十年中，使用纳米硒和纳米碲作为对抗肿瘤的攻击性武器的新型癌症治疗策略出现了爆炸式增长。实际上，它们都是抑制肿瘤细胞增殖，扩散和转移的无机纳米药物。合理的，精确的纳米硒和纳米碲表面装饰的丰富合成策略使它们成为强大的多模式治疗方法中抵抗癌症的重要参与者。这篇综述主要关注基于纳米硒和纳米碲的纳米传递系统的设计和工程及其在癌症治疗中的精确用途。详细讨论了纳米硒和纳米碲的相应抗癌分子机制。考虑到它们的光诱导行为不同，在描述nano-Se和nano-Te的抗癌应用时，将近红外照明的存在与否作为定义特征。最后，总结并强调了纳米硒和纳米碲的挑战和未来前景。
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