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A facile synthesis of trisubstituted allenamides by DBU-promoted isomerization of propargylamides
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-06-13 , DOI: 10.1016/j.tetlet.2020.152146 Tsukasa Hirokane , Shino Watanabe , Kenji Matsumoto , Masahiro Yoshida
中文翻译:
通过DBU促进的炔丙基酰胺的异构化轻松合成三取代的烯丙基酰胺
更新日期:2020-07-05
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-06-13 , DOI: 10.1016/j.tetlet.2020.152146 Tsukasa Hirokane , Shino Watanabe , Kenji Matsumoto , Masahiro Yoshida
Trisubstituted allenamides are synthesized by the isomerization of propargylamides with DBU. The reactions afforded a variety of substituted allenamides under simple and mild conditions. One-pot synthesis of allenamides from propargylamines, which were easily prepared by aldehyde-alkyne-amine coupling in one-step, is also achieved.
中文翻译:
通过DBU促进的炔丙基酰胺的异构化轻松合成三取代的烯丙基酰胺
三取代的烯丙基酰胺是通过炔丙基酰胺与DBU异构化合成的。反应在简单温和的条件下得到了各种取代的烯丙酰胺。还实现了由炔丙基胺的一锅法合成烯丙酰胺,很容易通过一步一步的醛-炔-胺偶联制备。