An economical and reliable theranostic unit is essential for the detection and treatment of bacterial infections. MRSA is one of the most prevalent superbugs in the world at present, hence requires urgent attention. Here, we present a novel copper-based 3-D porous nanocomposite modified with vancomycin (Van) for simultaneous detection and treatment of methicillin-resistant S. aureus (MRSA). The composite contains copper/copper oxide nanoparticles which are reduced by the hydroxyl groups of β-cyclodextrin (β-CD). On addition of graphene oxide (GO), it achieves a porous structure due to π-π stacking and formation of hydrogen bonds between β-cyclodextrin (β-CD) and reduced graphene oxide sheets. Conjugation of Van to the composite provides highly specific binding towards gram-positive bacteria. Differential pulse voltammetry (DPV) was used to carry out the electrochemical detection of MRSA and achieved a very low limit of detection (LOD) 5 CFU mL⁻¹ along with a minimum inhibitory concentration (MIC) value of 1.93 μg mL⁻¹. The low LOD and MIC values are due to the good electrochemical response of the composite and the synergetic antibacterial effect of vancomycin and copper/copper oxide nanoparticles, respectively. The current work provides a more effective and economic unit as electrode modifier simultaneous detection and powder for the elimination of pathogenic bacteria.

经济和可靠的治疗学部门对于细菌感染的检测和治疗至关重要。MRSA是目前世界上最流行的超级错误之一，因此需要紧急关注。在这里，我们介绍了一种新型的铜基3-D多孔纳米复合材料，用万古霉素（Van）修饰，可同时检测和治疗耐甲氧西林的金黄色葡萄球菌。（MRSA）。该复合物包含被β-环糊精（β-CD）的羟基还原的铜/铜氧化物纳米颗粒。在添加氧化石墨烯（GO）时，由于π-π堆积以及在β-环糊精（β-CD）和还原的氧化石墨烯片之间形成氢键，从而获得了多孔结构。Van与复合物的结合为革兰氏阳性菌提供了高度特异性的结合。使用差分脉冲伏安法（DPV）进行MRSA的电化学检测，并实现了非常低的检测限（LOD）5 CFU mL ^-1和最小抑制浓度（MIC）值1.93μgmL ^-1。低的LOD和MIC值分别是由于复合材料的良好电化学响应以及万古霉素和铜/铜氧化物纳米粒子的协同抗菌作用。当前的工作提供了一种更有效和经济的单元，可同时检测电极修饰剂和消灭病原细菌的粉末。