The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis.

中文翻译：

---

无义介导的 mRNA 衰变途径与病毒感染之间的“军备竞赛”

无义介导的 mRNA 衰减 (NMD) 途径是在真核细胞中保守的 RNA 质量控制途径。虽然历史上认为主要识别具有提前终止密码子的转录本，但现在已知 NMD 途径发挥着多种作用，从稳态事件到控制病毒病原体。在这篇综述中，我们强调了宿主 NMD 途径和病毒病原体之间的相互作用，这些相互作用塑造了宿主抗病毒防御和病毒发病机制。