In rodent models of Autism Spectrum Disorders (ASD), the study of ultrasonic vocalizations has provided the unique opportunity to evaluate social communication and interaction in ethologically-appropriate contexts, behavioral domains relevant to the first core symptom of ASD. In the present review, we selected and evaluated ultrasonic vocalizations’ data collected in rodent models of ASD in different experimental settings, either in the neonatal phase or in adulthood. Both quantitative (calling rates) and qualitative (range and shape of the vocal repertoire) abnormalities have been evidenced. The aim of our work was to highlight several promises and a few caveats in the use of ultrasonic vocalizations for behavioral phenotyping of ASD models and give some suggestions to maximize the translational value of these studies.

在自闭症谱系障碍（ASD）的啮齿动物模型中，对超声发声的研究提供了独特的机会，可以在符合伦理学的情境下（与ASD的第一个核心症状相关的行为领域）评估社交交流和互动。在本综述中，我们选择并评估了在新生儿期或成年期不同实验环境下在ASD啮齿动物模型中收集的超声发声数据。定量（呼叫率）和定性（声音库的范围和形状）异常均已得到证明。我们工作的目的是强调在使用超声发声技术进行ASD模型的行为表型分析时的一些希望和一些警告，并提出一些建议以使这些研究的翻译价值最大化。