Zebrafish are now widely accepted as a valuable animal model for a number of different central nervous system (CNS) diseases. They are suitable both for elucidating the origin of these disorders and the sequence of events culminating in their onset, and for use as a high-throughput in vivo drug screening platform. The availability of powerful and effective techniques for genome manipulation allows the rapid modelling of different genetic epilepsies and of conditions with seizures as a core symptom. With this review, we seek to summarize the current knowledge about existing epilepsy/seizures models in zebrafish (both pharmacological and genetic) and compare them with equivalent rodent and human studies. New findings obtained from the zebrafish models are highlighted. We believe that this comprehensive review will highlight the value of zebrafish as a model for investigating different aspects of epilepsy and will help researchers to use these models to their full extent.

斑马鱼现已被广泛接受为许多不同的中枢神经系统（CNS）疾病的有价值的动物模型。它们既适合于阐明这些疾病的起源以及最终导致其发作的事件序列，也适合用作体内高通量的药物。药物筛选平台。基因组操作的强大而有效的技术的可用性允许快速建模不同的遗传性癫痫和以癫痫为核心症状的疾病。通过这篇综述，我们试图总结关于斑马鱼现有癫痫/癫痫模型的现有知识（药理和遗传学），并将其与等效的啮齿动物和人体研究相比较。从斑马鱼模型获得的新发现突出显示。我们认为，这项全面的综述将突出斑马鱼作为研究癫痫不同方面的模型的价值，并将帮助研究人员充分利用这些模型。