The age-associated decline of regenerative capacity in many tissues is a consequence of stem cell intrinsic and extrinsic perturbations that are only beginning to be understood. To gain insight into mechanisms of this age-related decline, a comprehensive understanding of these perturbations is necessary. Drosophila intestinal stem cells (ISCs) have served as a prime model in which to explore these age-related changes, and in which to identify intervention strategies to improve regenerative capacity and extend lifespan. In this review, we summarize and discuss important work that has contributed to our understanding of how aging impacts ISC regulation in relation to well-described “hallmarks” of aging.

许多组织中与年龄相关的再生能力下降是干细胞内在和外在扰动的结果，这些扰动才刚刚开始被理解。为了深入了解这种与年龄相关的衰退机制，有必要全面了解这些扰动。果蝇肠道干细胞 (ISC) 已成为探索这些与年龄相关的变化以及确定干预策略以提高再生能力和延长寿命的主要模型。在这篇综述中，我们总结并讨论了重要的工作，这些工作有助于我们理解老龄化如何影响与详细描述的老龄化“标志”相关的 ISC 监管。