Abstract An alternative approach for rapid, highly sensitive and specific analytical sensor for the simultaneous determination of fat-soluble vitamins (A, D, E and K) in different matric samples was demonstrated using our developed sensor by graphene nanocomposite. The adsorptive square wave voltammetry was used to determine the amounts of vitamin A, D, E and K in infant milk, yogurt and parsley. Various analytical conditions were investigated to enhance the best performance of the proposed method. Under optimal conditions, a good linear relationship was obtained between the anodic current and the concentration of vitamins within the range from 0.02 μg mL−1 to 1 μg mL−1. The limits of detection were found to be 0.0086, 0.0063, 0.0075 and 0.0071 μg mL−1 for vitamin A, D, E and K, respectively. The accuracy of the proposed sensor has been validated with the standard AOAC guideline. The reproducibility has also been demonstrated by repeating the experiments between sensor-to-sensor. Compared to conventional chromatographic methods, the electrochemical sensor outlined here shows a comparable performance yet faster, simpler, and cheaper approach that enables the continuous monitoring of the total quantity of vitamin A, D, E and K in various samples with good reliability, sensitivity, selectivity and accuracy.

中文翻译：

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高效石墨烯纳米复合材料：应用于不同基质样品中脂溶性维生素的快速同时鉴定和定量

摘要 使用我们开发的石墨烯纳米复合材料传感器展示了一种用于同时测定不同基质样品中脂溶性维生素（A、D、E 和 K）的快速、高灵敏度和特异性分析传感器的替代方法。吸附式方波伏安法用于测定婴儿牛奶、酸奶和欧芹中维生素 A、D、E 和 K 的含量。研究了各种分析条件，以提高所提出方法的最佳性能。在最佳条件下，阳极电流与维生素浓度在 0.02 μg mL-1 至 1 μg mL-1 范围内具有良好的线性关系。发现维生素 A、D、E 和 K 的检测限分别为 0.0086、0.0063、0.0075 和 0.0071 μg mL-1。所提议的传感器的准确性已通过标准 AOAC 指南进行了验证。通过重复传感器到传感器之间的实验也证明了可重复性。与传统的色谱方法相比，此处概述的电化学传感器显示出一种类似的性能但更快、更简单和更便宜的方法，可以连续监测各种样品中维生素 A、D、E 和 K 的总量，并具有良好的可靠性、灵敏度、选择性和准确性。