Abstract The distinctive bimetallic metal-organic framework based on Cu@Ni microsphere with a solid ball-like structure is successfully synthesized by a two-step hydrothermal reaction. Their structural morphology and bimetallic composition are characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), energy dispersive X-ray (EDX), respectively. The as-prepared bimetallic Cu@Ni organic framework can be modified on the glassy carbon electrode (GCE) and used for the non-enzymatic glucose sensor in an alkaline solution that exhibits better electrocatalytic activity relative to the individual material. The electrochemical analysis demonstrated that the developed sensor had superior electrocatalytic activity towards glucose oxidation, it exhibits a high sensitivity of 496 μA.mM−1 in the range from 0 to 5 mM, limit of detection (LOD) of 0.4 μM and excellent selectivity with the signal to noise ratio (S/N) of 3. The superior catalytic performance towards glucose is mainly supported by the synergistic effect of Cu and Ni MOF. The fabricated glucose sensor also provided good performances in the investigation of real samples. Exploring different insights into the development of a new MOF based bimetallic nanostructure non-enzymatic glucose sensor with reasonable cost and good stability.

中文翻译：

---

金属有机骨架辅助双金属Ni@Cu微球用于葡萄糖的无酶电化学传感

摘要 通过两步水热反应成功合成了具有固体球状结构的基于Cu@Ni微球的独特双金属金属有机骨架。它们的结构形貌和双金属组成分别通过扫描电子显微镜 (SEM)、透射电子显微镜 (TEM)、X 射线衍射 (XRD)、能量色散 X 射线 (EDX) 进行表征。所制备的双金属 Cu@Ni 有机骨架可以在玻璃碳电极 (GCE) 上进行修饰，并在碱性溶液中用于非酶葡萄糖传感器，相对于单个材料表现出更好的电催化活性。电化学分析表明，所开发的传感器对葡萄糖氧化具有优异的电催化活性，灵敏度高达 496 μA。mM-1 在 0 至 5 mM 范围内，检测限 (LOD) 为 0.4 μM，具有出色的选择性，信噪比 (S/N) 为 3。对葡萄糖的优异催化性能主要由协同作用支持Cu和Ni MOF的影响。制造的葡萄糖传感器在实际样品的研究中也提供了良好的性能。探索不同的见解，开发一种新的基于 MOF 的双金属纳米结构非酶葡萄糖传感器，具有合理的成本和良好的稳定性。