STIM1, an ER-located Ca2+ sensor, activates Orai1 channels upon Ca2+-storedepletion. Prior to this, STIM1 undergoes a sequence of conformational changes, which cannot be controlled individually with high spatiotemporal resolution. Ma et al. [1] used the power of optogenetic engineering to transfer light-sensitivity to STIM1 and precisely characterize individual STIM1 activation steps.

中文翻译：

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自然光开关公开了 STIM1 激活步骤。

STIM1 是一种位于 ER 的 Ca2+ 传感器，可在 Ca2+ 存储耗尽时激活 Orai1 通道。在此之前，STIM1 会经历一系列构象变化，这些变化无法通过高时空分辨率单独控制。马等。[1] 利用光遗传工程的力量将光敏性转移到 STIM1 并精确表征单个 STIM1 激活步骤。