Hypoxia is a serious impediment to current treatments of many malignant tumors. Catalase, an antioxidant enzyme, is capable of decomposing endogenous hydrogen peroxide (H₂O₂) into oxygen for tumor reoxygenation, but suffered from in vivo instability and limited delivery to deep interior hypoxic regions in tumor. Herein, a deep-penetrated nanocatalase-loading DiIC₁₈ (5, DiD) and soravtansine (Cat@PDS) were provided by coating catalase nanoparticles with PEGylated phospholipids membrane, stimulating the structure and function of erythrocytes to relieve tumor hypoxia for enhanced chemo-photodynamic therapy. After intravenous administration, Cat@PDS preferentially accumulated at tumor sites, flexibly penetrated into the interior regions of tumor mass and remarkably relieved the hypoxic status in tumor. Notably, the Cat@PDS + laser treatment produced striking inhibition of tumor growth and resulted in a 97.2% suppression of lung metastasis. Thus, the phospholipids membrane-coated nanocatalase system represents an encouraging nanoplatform to relieve tumor hypoxia and synergize the chemo-photodynamic cancer therapy.

缺氧严重阻碍了目前许多恶性肿瘤的治疗。过氧化氢酶是一种抗氧化酶，能够将内源性过氧化氢（H ₂ O ₂）分解为氧气以进行肿瘤的重新氧合，但存在体内不稳定性和向肿瘤内部深部缺氧区域的传递受限的问题。在这里，深穿透纳米过氧化氢酶的DiIC ₁₈通过用聚乙二醇化的磷脂膜包被过氧化氢酶纳米粒子，提供红细胞（5，DiD）和索拉丹宁（Cat @ PDS），刺激红细胞的结构和功能以减轻肿瘤缺氧，从而增强化学光动力疗法。静脉内给药后，Cat @ PDS优先聚集在肿瘤部位，可以灵活地渗透到肿瘤块的内部区域，并显着缓解肿瘤中的低氧状态。值得注意的是，Cat @ PDS +激光治疗显着抑制了肿瘤的生长，并抑制了97.2％的肺转移。因此，磷脂膜包被的纳米过氧化氢酶系统代表了令人鼓舞的纳米平台，以减轻肿瘤的缺氧并协同化学光动力癌症治疗。