Abstract The combined effect of melatonin and cytarabin at low concentration on the cells of acute promyelocytic leukemia HL-60 was studied. It has been shown that the combined effect of these substances led to a decrease in the number of cells by 70% and the mitotic activity index by 75%. It was found that the combined effect of melatonin and cytarabin also contributed to a decrease in the expression of mitochondrial proteins. It has been demonstrated that the combined use of melatonin with low concentration of cytarabin (2 nM) reduced the expression of the voltage-dependent anion channel (VDAC1). Melatonin in combination with cytarabin similarly affected the expression of translocator protein (TSPO) and antiapoptotic protein Bcl-2. The synergistic effect of melatonin in the combined action with cytarabin has been revealed, which provides an increase in the effectiveness of its antitumor action.

中文翻译：

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褪黑激素增强阿糖胞苷对 HL-60 细胞的化疗作用

摘要 研究了低浓度褪黑激素和阿糖胞苷对急性早幼粒细胞白血病HL-60细胞的联合作用。已经表明，这些物质的联合作用导致细胞数量减少 70%，有丝分裂活动指数减少 75%。发现褪黑激素和阿糖胞苷的联合作用也有助于降低线粒体蛋白的表达。已经证明，褪黑激素与低浓度阿糖胞苷 (2 nM) 的联合使用降低了电压依赖性阴离子通道 (VDAC1) 的表达。褪黑激素与阿糖胞苷的组合同样影响易位蛋白 (TSPO) 和抗凋亡蛋白 Bcl-2 的表达。褪黑激素在与阿糖胞苷联合作用中的协同作用已被揭示，