Abstract

Mono- and binuclear complexes [Cu(Fur)₂(Phen)] (I), [Cu₂(Fur)₄(Py)₂] (II), [Cu(Fur)₂-(Py)₂(H₂O)] (III), and [Zn₂(Fur)₄L₂] (L = Py (IV), Phpy (V)) are synthesized using the reactions of copper(II) and zinc(II) acetates with anions of pyromucic acid (2-furancarboxylic acid (HFur)) and N‑donor ligands (pyridine (Py), 4-phenylpyridine (Phpy), and 1,10-phenanthroline (Phen)) in acetonitrile. The copper complexes with pyridine are successively formed from the same reaction mixture: at first binuclear complex II is formed and then mononuclear complex III is formed. All compounds are isolated as single crystals, and their structures are determined by X-ray structure analysis (CIF files CCDC nos. 1974386 (I), 1974388 (II), 1974389 (III), 1974387 (IV), and 1974385 (V)). The thermal behavior of complexes II and III is studied by simultaneous thermal analysis. The biological activity in vitro of all complexes is determined toward the nonpathogenic mycobacterial strain Mycolicibacterium smegmatis. Complexes I and V exhibit a high biological activity and are promising for further studies of antitubercular activity.

中文翻译：

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焦磷酸阴离子和N-供体对Cu 2+和Zn 2+的生物等排修饰：合成，结构，热性质和生物活性

摘要

单核和双核络合物[Cu（Fur）₂（Phen）]（I），[Cu ₂（Fur）₄（Py）₂ ]（II），[Cu（Fur）_2-（Py）₂（H ₂ O ）]（III）和[Zn ₂（Fur）₄ L ₂ ]（L = Py（IV），Phpy（V））是利用乙酸铜（II）和乙酸锌（II）与焦果酸（2-呋喃甲酸（HFur））和N-给体配体（吡啶（Py），4-苯基吡啶（Phpy），和在乙腈中的1,10-菲咯啉（Phen））。由相同的反应混合物依次形成具有吡啶的铜配合物：首先形成双核配合物II，然后形成单核配合物III。所有化合物均以单晶形式分离，并通过X射线结构分析确定其结构（CIF文件CCDC 1974386（I），1974388（II），1974389（III），1974387（IV）和1974385（V） ）。配合物的热行为通过同时热分析研究II和III。确定了所有复合物对非致病性分枝杆菌耻垢分枝杆菌的体外生物活性。配合物I和V表现出高的生物学活性，并有望用于抗结核活性的进一步研究。