The CaMK subfamily of Ser/Thr kinases are regulated by calmodulin interactions with their C-terminal regions. They are exemplified by Ca²⁺/calmodulin dependent protein kinase 1δ which is known as CaMK1D, CaMKIδ or CKLiK. CaMK1D mediates intracellular signalling downstream of Ca²⁺ influx and thereby exhibits amplifications of Ca²⁺signals and polymorphisms that have been implicated in breast cancer and diabetes. Here we report the backbone ¹H, ¹³C, ¹⁵N assignments of the 38 kDa human CaMK1D protein in its free state, including both the canonical bi-lobed kinase fold as well as the autoinhibitory and calmodulin binding domains.

中文翻译：

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Ca2+/钙调蛋白依赖性蛋白激酶 1D 的催化和调节结构域的骨架共振分配。

Ser/Thr 激酶的 CaMK 亚家族受钙调蛋白与其 C 端区域的相互作用的调节。它们的示例是 Ca ²⁺ /钙调蛋白依赖性蛋白激酶 1δ，它被称为 CaMK1D、CaMKIδ 或 CKLiK。CaMK1D 介导 Ca ²⁺流入下游的细胞内信号传导，从而表现出与乳腺癌和糖尿病有关的 Ca ²⁺信号和多态性的放大。在这里，我们报告了处于游离状态的 38 kDa 人类 CaMK1D 蛋白的骨架¹ H、¹³ C、¹⁵ N 分配，包括典型的双叶激酶折叠以及自身抑制和钙调蛋白结合域。