Organic/inorganic nanocomposites for cancer immunotherapy,Materials Chemistry Frontiers

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Organic/inorganic nanocomposites for cancer immunotherapy
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2020-06-13 , DOI: 10.1039/d0qm00323a
Mingqiang Hao _{1,

2,

3,

4,

5} , Beibei Chen _{1,

2,

3,

4,

5} , Xiaoyi Zhao _{1,

2,

3,

4,

5} , Nana Zhao _{1,

2,

3,

4,

5} , Fu-Jian Xu _{1,

2,

3,

4,

5}

Affiliation

Cancer immunotherapy provides an effective way to deal with cancer. Although immunotherapy strategies have shown encouraging therapeutic effects, the inherent limitations of immunotherapy, such as multiple tumor immune evasion methods, low response rate, and systemic toxicity, still hinder its clinical applications. In recent decades, nanomaterials have been considered promising in cancer immunotherapy since they can realize targeted delivery and interact with the immune system to induce or enhance the antitumor immune responses. Among them, organic/inorganic nanocomposites are ideal candidates for cancer immunotherapy since they could combine the advantages of both organic and inorganic components. Multifunctional organic/inorganic nanocomposites could help overcome the shortcomings of current cancer immunotherapy, and realize the combination of immunotherapy and other therapeutic strategies with synergistic antitumor effects. Herein, we review the recent progress of organic/inorganic nanocomposites designed for cancer immunotherapy. The immunotherapy strategies of nanocomposites are summarized from the perspective of achieving immune enhancement. The challenges of nanocomposites in cancer immunotherapy are also discussed.

中文翻译：

用于癌症免疫治疗的有机/无机纳米复合材料

癌症免疫疗法提供了治疗癌症的有效方法。尽管免疫疗法已显示出令人鼓舞的治疗效果，但免疫疗法的固有局限性（例如多种肿瘤免疫逃避方法，低应答率和全身毒性）仍然阻碍了其临床应用。在最近几十年中，纳米材料被认为在癌症免疫治疗中很有前途，因为它们可以实现靶向递送并与免疫系统相互作用，以诱导或增强抗肿瘤免疫反应。其中，有机/无机纳米复合材料是癌症免疫疗法的理想选择，因为它们可以结合有机和无机成分的优点。多功能有机/无机纳米复合材料可帮助克服当前癌症免疫疗法的缺点，并实现免疫疗法与其他具有协同抗肿瘤作用的治疗策略的结合。本文中，我们综述了用于癌症免疫治疗的有机/无机纳米复合材料的最新进展。从实现免疫增强的角度总结了纳米复合材料的免疫治疗策略。还讨论了纳米复合材料在癌症免疫治疗中的挑战。

更新日期：2020-06-13

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