Spathodea campanulata P. Beauv. (Bignoniaceae) is a very common plant in Bangladesh which is locally called “Rudrapalash”. In Nigeria leaves extract of S. campanulata has a reputation of being used as an anticonvulsant. In this connection, the aim of this study was to investigate other neuropharmacological effects like sedative and anxiolytic activities of methanol extract of S. campanulata (MESC) leaves in different mice tests. To assay sedative activity mice were subjected to open field and hole-cross test, whereas anxiolytic activity was checked by the elevated-plus maze, light-dark box, and hole-board test. For each test, mice were divided into control group (deionized water, 0.1 ml/mouse, p.o.), standard group (diazepam, 1 mg/kg, i.p) and three test groups (200, 400 and 600 mg/kg MESC, p.o.). The acute toxicity test and phytochemical screening of MESC were performed before the pharmacological study. The result demonstrated strong sedative and anxiolytic activity of MESC in a dose-dependent manner. All doses of MESC (200, 400 & 600 mg/kg) reduced the number of (square & hole) crossed by mice in both open field and hole cross tests (p < 0.001). On the other hand, in elevated plus-maze and light-dark box test mice opted to stay more in open arms and light box instead of close arms and dark box (p < 0.001). In hole-board test MESC (200, 400 & 600 mg/kg) elevated the number of head dipping (p < 0.001) dose-dependently. Phytochemical investigation indicated the presence of alkaloid, saponin, glycoside, carbohydrate, flavonoid, and tannin in MESC. The experimental results explicit that S. campanulata leaves possess sedative and anxiolytic activities, hence suggest further chemical investigation to identify specific phytoconstituents responsible for sedative and anxiolytic effects.

中文翻译：

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Spathodea campanulata P.（Beauv。）叶片的甲醇提取物对瑞士白化病小鼠表现出镇静和抗焦虑作用

Spathodea campanulata体育。（Bignoniaceae）是孟加拉国非常普遍的植物，当地称为“ Rudrapalash”。在尼日利亚，桔梗叶提取物具有用作抗惊厥药的声誉。就此而言，本研究的目的是研究其他神经药理作用，例如在不同小鼠试验中的桔梗（S. campanulata）叶甲醇提取物（MESC）的镇静和抗焦虑活性。为了测定镇静活性，对小鼠进行旷场和孔交叉测试，而抗焦虑活性通过高架迷宫，明暗盒和孔板测试进行检查。对于每个测试，将小鼠分为对照组（去离子水，0.1 ml /小鼠，口服），标准组（地西p，1 mg / kg，腹膜内）和三个测试组（200、400和600 mg / kg MESC，口服） ）。在进行药理学研究之前，对MESC进行了急性毒性试验和植物化学筛选。该结果证明了MESC的强镇静和抗焦虑活性呈剂量依赖性。在露天视野和孔交叉测试中，所有剂量的MESC（200、400和600 mg / kg）均减少了小鼠穿过的（方孔）数量（p <0.001）。另一方面，在高迷迷宫和浅色暗盒中，测试小鼠选择了更多地呆在张开的手臂和浅色的盒子中，而不是紧贴的手臂和深色的盒子（p <0.001）。在孔板试验中，MESC（200、400和600 mg / kg）剂量依赖性地增加了浸头次数（p <0.001）。植物化学研究表明，MESC中存在生物碱，皂苷，糖苷，碳水化合物，类黄酮和鞣质。实验结果表明，S。