Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive. An up-to-date meta-analysis was conducted on the basis of studies selected from PubMed, WanFang database, Embase, Vip database, Web of Science, Scopus, and CNKI database. A total of 33 studies conferring 3266 cases and 3259 controls were selected on the basis of criteria of inclusion and exclusion in this meta-analysis. For APOE alleles, the pooled odds ratio (OR) of ε2 vs. ε3 was 1.89 (95% confidence intervals [95% CI]: 1.49–2.38, P < 0.0001). With regard to APOE genotypes, ε2/ε2, ε2/ε3, and ε2/ε4 increased the risk of T2DN (ε2/ε2 vs. ε3/ε3: OR = 2.32, 95% CI: 1.52–3.56, P = 0.0001; ε2/ε3 vs. ε3/ε3: OR = 1.97, 95% CI: 1.50–2.59, P<0.0001; ε2/ε4 vs. ε3/ε3: OR = 1.69, 95% CI: 1.18–2.44, P = 0.0046). This meta-analysis found that the APOE ε2 allele and the ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) are the risk factors of T2DN.

中文翻译：

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ε2等位基因和ε2相关基因型（ε2/ε2，ε2/ε3和ε2/ε4）可能将APOE基因多态性与2型糖尿病肾病风险相关联：一项荟萃分析。

糖尿病肾病（DN）导致晚期肾功能衰竭。活性氧引起的微血管损伤与DN的发病机制有关。载脂蛋白E（APOE）的遗传多态性影响该蛋白的抗氧化特性。在2型糖尿病（T2DN）中，APOE多态性与肾病风险的关系仍然难以捉摸。根据选自PubMed，WanFang数据库，Embase，Vip数据库，Web of Science，Scopus和CNKI数据库的研究，进行了最新的荟萃分析。根据这项荟萃分析的纳入和排除标准，共选择33项研究，共3266例病例和3259例对照。对于APOE等位基因，ε2与ε3的合并比值比（OR）为1.89（95％置信区间[95％CI]：1.49–2.38，P <0.0001）。对于APOE基因型，ε2/ε2，ε2/ε3和ε2/ε4增加了T2DN的风险（ε2/ε2与ε3/ε3：OR = 2.32，95％CI：1.52-3.56，P = 0.0001；ε2 /ε3与ε3/ε3：OR = 1.97，95％CI：1.50–2.59，P <0.0001；ε2/ε4与ε3/ε3：OR = 1.69，95％CI：1.18–2.44，P = 0.0046）。这项荟萃分析发现，APOEε2等位基因和涉及ε2的基因型（ε2/ε2，ε2/ε3和ε2/ε4）是T2DN的危险因素。