Background. Sestrins (Sesns), a group of oxidative stress-related proteins, have been reported to be involved in various cardiovascular diseases, including aortic dissection and chronic heart failure. This study is aimed at investigating the level of circulating Sesn1, Sesn2, and Sesn3 in hypertension patients. Methods. Plasma levels of Sesn1, Sesn2, and Sesn3 in 400 hypertensive patients and 100 normotensive subjects were detected using enzyme-linked immunosorbent assay (ELISA) kits. The hypertension patients were divided into groups with grade I (), grade II (), and grade III () hypertension. Results. Compared with the normotensive subjects, Sesn1, Sesn2, and Sesn3 levels were increased in patients with hypertension, with a gradual increase between the groups with grade I, grade II, and grade III hypertension. Elevated Sesn1, Sesn2, and Sesn3 levels were positively correlated with both the systolic blood pressure (SBP) and diastolic blood pressure (DBP). Moreover, Sesn1, Sesn2, and Sesn3 levels were elevated in patients with dipper hypertension and further increased in patients with nondipper hypertension. In addition, smokers, as well as patients with higher levels of angiotensin II (Ang II) and carotid atherosclerotic plaque (CAP), exhibited increased Sesn1, Sesn2, and Sesn3 levels when compared with patients without these clinical characteristics. Furthermore, plasma levels of Sesn1, Sesn2, and Sesn3 were negatively correlated with the presence of CAP. Conclusions. Circulating Sesn levels are increased in patients with hypertension and may be a target for the prevention and treatment of clinical hypertension.

中文翻译：

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高血压患者的循环 Sestrin 水平升高。

背景。Sestrins (Sesns) 是一组与氧化应激相关的蛋白质，据报道与各种心血管疾病有关，包括主动脉夹层和慢性心力衰竭。本研究旨在调查高血压患者的循环 Sesn1、Sesn2 和 Sesn3 水平。方法。使用酶联免疫吸附试验 (ELISA) 试剂盒检测了 400 名高血压患者和 100 名血压正常受试者的血浆 Sesn1、Sesn2 和 Sesn3 水平。高血压患者分为Ⅰ级（),二级 ()和 III 级 ()高血压。结果. 与血压正常者相比，高血压患者Sesn1、Sesn2、Sesn3水平升高，I级、II级、III级高血压组间呈逐渐升高趋势。Sesn1、Sesn2 和 Sesn3 水平升高与收缩压 (SBP) 和舒张压 (DBP) 均呈正相关。此外，杓型高血压患者的 Sesn1、Sesn2 和 Sesn3 水平升高，非杓型高血压患者进一步升高。此外，与没有这些临床特征的患者相比，吸烟者以及血管紧张素 II (Ang II) 和颈动脉粥样硬化斑块 (CAP) 水平较高的患者的 Sesn1、Sesn2 和 Sesn3 水平升高。此外，Sesn1、Sesn2 的血浆水平，结论。高血压患者的循环Sesn水平升高，可能是临床高血压防治的靶点。