当前位置: X-MOL 学术Annu. Rev. Anal. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Clinically Relevant Tissue Scale Responses as New Readouts from Organs-on-a-Chip for Precision Medicine
Annual Review of Analytical Chemistry ( IF 5.9 ) Pub Date : 2020-06-12 , DOI: 10.1146/annurev-anchem-061318-114919
Olivier T. Guenat 1, 2, 3 , Thomas Geiser 2 , François Berthiaume 4
Affiliation  

Organs-on-chips (OOC) are widely seen as being the next generation in vitro models able to accurately recreate the biochemical-physical cues of the cellular microenvironment found in vivo. In addition, they make it possible to examine tissue-scale functional properties of multicellular systems dynamically and in a highly controlled manner. Here we summarize some of the most remarkable examples of OOC technology's ability to extract clinically relevant tissue-level information. The review is organized around the types of OOC outputs that can be measured from the cultured tissues and transferred to clinically meaningful information. First, the creation of functional tissues-on-chip is discussed, followed by the presentation of tissue-level readouts specific to OOC, such as morphological changes, vessel formation and function, tissue properties, and metabolic functions. In each case, the clinical relevance of the extracted information is highlighted.

中文翻译:


与临床相关的组织规模反应,作为精确医学的单芯片器官新读数

芯片上的器官(OOC)被广泛认为是下一代体外模型,能够准确地再现体内发现的细胞微环境的生化物理线索。此外,它们使动态检查高度受控的多细胞系统的组织级功能特性成为可能。在这里,我们总结了OOC技术提取临床相关组织水平信息的能力的一些最杰出的例子。审查围绕OOC输出的类型进行组织,可以从培养的组织中进行测量,然后将其转换为具有临床意义的信息。首先,讨论了功能性片上组织的创建,然后介绍了OOC特有的组织水平读数,例如形态变化,血管形成和功能,组织特性,和代谢功能。在每种情况下,突出显示提取信息的临床相关性。

更新日期:2020-06-12
down
wechat
bug