Inorganic drugs, especially polyoxometalate-based hybrids, are expected to be developed as promising future metallodrugs. Herein, an organic–inorganic hybrid solid based on pyridine-2-carboxylic acid or picolinic acid (pic), [(Cu(pic)₂)₂(Mo₈O₂₆)]·8H₂O (1), was synthesized. A single-crystal structure of a solid possesses a discrete β-type octamolybdate cluster that supramolecularly aggregates with a {Cu₂(pic)₄}^4– complex and eight lattice water molecules. The study indicates that the solid is stable in aqueous medium and less toxic toward normal cell lines. The in vitro anti-bacterial and anti-tumor properties of the solid 1 were investigated. The results of the anti-tumor action against various human cancer cell lines, namely, lung (A549), breast (MCF-7), and liver (HepG2) cancer cells suggest that this β-octamolybdate-based solid yielded the lowest IC₅₀ value reported so far among octamolybdate anion-based hybrid solids, i.e., 24.24 μM for MCF-7, 21.56 μM for HepG2, and 25 μM for A549, indicating significant anti-cancer activity. The cell cycle analysis further reveals the observed anti-tumor effect to be governed by the arrest of breast cancer cells in the G2/M phase while that of lung and liver cancer cells in the S phase of the cell cycle. A fluorescence quenching study suggests the binding interaction between solid and ctDNA, which in turn induces apoptosis and necrosis pathways leading to cancer cell death. This is also the first study of {Mo₈O₂₆}^4– cluster-based solids as an anti-bacterial agent against Escherichia coli, and it was found to be very effective with a minimal inhibitory concentration value of ∼135 μg/mL, which is the lowest so far reported for any octamolybdate-based solid.

中文翻译：

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与吡啶甲酸铜络合物结合的八钼酸盐簇基杂化固体的体外抗肿瘤和抗菌活性

无机药物，尤其是基于多金属氧酸盐的杂化物，有望被开发为有前途的金属药物。在此，合成了基于吡啶-2-羧酸或吡啶甲酸(pic)的有机-无机杂化固体[(Cu(pic) ₂ ) ₂ (Mo ₈ O ₂₆ )]·8H ₂ O ( 1 )。固体的单晶结构具有离散的 β 型八钼酸盐簇，该簇与 {Cu ₂ (pic) ₄ } ^4-配合物和八个晶格水分子超分子聚集。研究表明，该固体在水性介质中稳定，对正常细胞系的毒性较小。体外的研究了固体1的抗菌和抗肿瘤特性。对各种人类癌细胞系，即肺癌 (A549)、乳腺癌 (MCF-7) 和肝癌 (HepG2) 癌细胞的抗肿瘤作用结果表明，这种基于 β-八钼酸盐的固体产生的 IC _50最低迄今为止报道的基于八钼酸盐阴离子的杂化固体中的值，即MCF-7为24.24μM，HepG2为21.56μM，A549为25μM，表明具有显着的抗癌活性。细胞周期分析进一步揭示了观察到的抗肿瘤作用受乳腺癌细胞在 G2/M 期的停滞以及肺癌和肝癌细胞在细胞周期的 S 期的停滞所支配。一项荧光猝灭研究表明，固体和 ctDNA 之间的结合相互作用，进而诱导细胞凋亡和坏死途径，导致癌细胞死亡。这也是第一次研究{Mo ₈ O ₂₆ } ^4-簇基固体作为抗大肠杆菌的抗菌剂，并且发现它非常有效，最小抑制浓度值约为 135 μg/mL，这是迄今为止报道的任何基于八钼酸盐的固体的最低值。