Indazolone‐Assisted Sequential ortho‐Alkenylation‐Oxidative Aza‐Michael Addition of 1‐Arylindazolone Using Acrylates Under Ru(II) Catalysis,Asian Journal of Organic Chemistry

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Indazolone‐Assisted Sequential ortho‐Alkenylation‐Oxidative Aza‐Michael Addition of 1‐Arylindazolone Using Acrylates Under Ru(II) Catalysis
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-06-12 , DOI: 10.1002/ajoc.202000239
Chikkagundagal K. Mahesha ₁ , Sanjay K. Mandal ₂ , Rajeev Sakhuja ₁

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A one‐pot annulation of 1‐arylindazolones and acrylates is achieved through Ru(II)‐catalyzed sequential ortho‐alkenylation followed by oxidative intramolecular aza‐Michael addition reaction to deliver substituted indazolo[1,2‐a ]indazolylidenes in good‐to‐excellent yields. The strategy showcased high functional group tolerance and the directing group ability of indazolone moiety was established for Csp²‐H bond activation.

中文翻译：

在Ru（II）催化下，使用丙烯酸酯对吲哚酮辅助的1-芳基吲唑酮的顺序邻位烯基化氧化性氮杂-迈克尔加成反应

1- arylindazolones的单釜环酯和丙烯酸酯是通过钌实现（II） -催化的连续邻-alkenylation随后氧化分子内氮杂迈克尔加成反应以提供取代的吲唑并[1,2-一个良好-TO-] indazolylidenes优异的产量。该策略显示了较高的官能团耐受性，并确定了吲唑酮部分的定向基团能力可用于Csp ² -H键激活。

更新日期：2020-08-08

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