Statement of problem

Incorporating chlorhexidine into soft lining materials has been suggested to reduce biofilm development on the material surface and treat denture stomatitis. However, evaluation of the physicochemical properties of this material is necessary.

Purpose

The purpose of this in vitro study was to evaluate the physicochemical properties of resin-based denture soft lining materials modified with chlorhexidine diacetate (CDA).

Material and methods

Two soft lining resins were tested, one based on polymethyl methacrylate (PMMA) and the other on polyethyl methacrylate (PEMA), into which 0.5%, 1.0%, or 2.0% of CDA was incorporated; the control group had no CDA. The specimens were stored for 2 hours, 48 hours, 7, 14, 21, and 28 days and then analyzed for polymer crystallinity, Shore A hardness, degree of monomer conversion, residual monomer leaching, and CDA release. Data were analyzed by using a 3-way ANOVA and the Tukey HSD test (α=.05).

Results

The polymer crystallinity of PEMA and PMMA did not change after CDA incorporation. Shore A hardness increased over time, but not for any CDA concentrations tested after 28 days (P>.05). Considering the degree of conversion, PMMA-based resin showed no statistically significant difference (P>.05). However, PEMA-based resin showed a significant decrease (P<.05), which was reflected in a significant increase in residual monomer leaching from PEMA-based resin with the incorporation of 0.5% and 1.0% CDA (P<.05), mainly in the first 48 hours. PMMA-based resin showed no change in monomer leaching (P>.05). For both resins, the CDA release kinetics were related to monomer leaching; for PEMA-based resin, the values were significantly higher in the first 48 hours (P<.05), and for PMMA-based resin, the values were more sustained up to the last day of analysis.

Conclusions

The incorporation of CDA did not affect the physicochemical properties of soft resins. The properties of PMMA were better than those of PEMA.

中文翻译：

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结合洗必太后对软衬树脂的理化性质进行体外评估。

问题陈述

已建议将氯己定掺入软衬材料中以减少材料表面的生物膜形成并治疗义齿口腔炎。但是，必须对该材料的物理化学性质进行评估。

目的

这项体外研究的目的是评估用双乙酸洗必泰（CDA）改性的树脂基假牙软衬材料的理化性质。

材料与方法

测试了两种软衬树脂，一种基于聚甲基丙烯酸甲酯（PMMA），另一种基于聚甲基丙烯酸乙酯（PEMA），其中掺入了0.5％，1.0％或2.0％的CDA；对照组没有CDA。将样品存储2小时，48小时，7、14、21和28天，然后分析聚合物的结晶度，肖氏A硬度，单体转化程度，残留单体浸出和CDA释放。使用三向方差分析和Tukey HSD测试（α= .05）分析数据。

结果

掺入CDA后，PEMA和PMMA的聚合物结晶度不变。肖氏A硬度随时间增加，但28天后测试的任何CDA浓度均未增加（P > .05）。考虑到转化程度，基于PMMA的树脂无统计学差异（P > .05）。但是，基于PEMA的树脂显示出显着降低（P <.05），这反映为通过掺入0.5％和1.0％的CDA，从PEMA-基树脂中浸出的残留单体显着增加（P <.05），主要在前48小时内。PMMA基树脂的单体浸出没有变化（P> .05）。对于这两种树脂，CDA释放动力学与单体浸出有关。对于PEMA基树脂，其值在开始的48小时内显着更高（P <.05），而对于PMMA基树脂，该值在分析的最后一天更为持久。

结论

CDA的掺入不影响软树脂的物理化学性质。PMMA的性能优于PEMA。