An efficient and highly eco-friendly approach to poly-substituted 1,6-naphthyridine derivatives with good to excellent yield has been reported using simple and readily available 4-aminopyridinone, aromatic aldehyde or isatin, and 1,3-cyclohexanedione as substrates. The method features low-cost and readily accessible starting materials, green ultrasonic irradiation in water, recycle heterogeneous solid acid catalyst, broad substrate scope as well as simple one-pot operation make this strategy highly attractive. Mechanistic studies indicate that this transformation involves Knoevenagel condensation, Michael addition, and cyclization sequence.

已经报道了使用简单且容易获得的4-氨基吡啶酮，芳族醛或靛红和1,3-环己二酮作为底物的高效且高度生态友好的方法，其具有良好至极佳收率的多取代1,6-萘啶衍生物。该方法具有低成本且易于获得的起始原料，水中绿色超声辐照，可循环使用的非均相固体酸催化剂，广泛的底物范围以及简单的一锅操作等特点，因此该方法具有很高的吸引力。机理研究表明，这种转化涉及Knoevenagel缩合，Michael加成和环化序列。