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Lanostane derivatives from the leaves and twigs of Garcinia wallichii
Phytochemistry Letters ( IF 1.3 ) Pub Date : 2020-06-12 , DOI: 10.1016/j.phytol.2020.05.005
Sasitorn Jaitheerapapkul , Chutima Kuhakarn , Sakchai Hongthong , Natthinee Anantachoke , Sariyarach Thanasansurapong , Arthit Chairoungdua , Kanoknetr Suksen , Narong Nuntasaen , Vichai Reutrakul

Bioassay-guided purification of the n-hexane and ethyl acetate extracts of the leaves and twigs of Garcinia wallichii led to the isolation of four previously undescribed lanostane triterpenes, wallichinanes F–I (14), together with four known compounds, wallichinane A (5), wallichinane B (6), friedelin (7), and lupeol (8). All structures were determined by means of spectroscopic techniques as well as comparison with literature data. Some isolated compounds were evaluated for cytotoxicity against a panel of cultured mammalian cancer cell lines. Wallichinanes G and H displayed weak cytotoxicity, whereas wallichinanes A, B, and F were found to be inactive in all the tested cell lines.



中文翻译:

藤黄叶子和树枝的羊毛脂衍生物

所述的生物测定引导的纯化ñ -己烷和乙酸乙酯的叶和枝条的提取物藤黄蕨导致四个以前未描述羊毛甾烷三萜类化合物的分离,wallichinanes F-I(1 - 4),加上四个已知化合物,wallichinane甲(5),Wallichinane B(6),Friedelin(7)和lupeol (8)。所有结构均通过光谱技术确定,并与文献数据进行比较。评价了一些分离的化合物对一组培养的哺乳动物癌细胞系的细胞毒性。Wallichinanes G和H表现出弱的细胞毒性,而Wallichinanes A,B和F在所有测试的细胞系中均无活性。

更新日期:2020-06-12
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