Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption and impair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. In addition, the peptide coating increases the bone-implant contact (BIC) by nearly 3 times resulting in suppressed osteoclastogenesis and promoted osteogenesis by inhibiting the nuclear factor kappa-B (NF-κB) signalling pathway. Our findings indicate that biomimetic peptides with osteoimmunomodulatory bioactivity can be incorporated into Ti-based prostheses to facilitate bone regeneration in patients with chronic inflammatory diseases.

系统性慢性炎症患者的骨内假体植入后通常会导致骨整合不良，这主要是由于促炎细胞因子的增加导致骨骼吸收并损害了骨形成。在这项工作中，设计了肽涂层植入物，以在假体周围创建有益的骨免疫微环境，从而促进界面成骨。通过利用自发性和稳定的配位化学，钛基植入物被贻贝启发肽包覆，以通过上调巨噬细胞的M2表型减轻脂多糖（LPS）诱导的炎症。此外，肽涂层将骨与植入物的接触（BIC）增加了近3倍，从而通过抑制核因子κB（NF-κB）信号传导途径抑制了破骨细胞并促进了成骨作用。我们的研究结果表明，具有骨免疫调节生物活性的仿生肽可以掺入基于Ti的假体中，以促进慢性炎症性疾病患者的骨再生。