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Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation.
Biomaterials ( IF 12.8 ) Pub Date : 2020-06-13 , DOI: 10.1016/j.biomaterials.2020.120197
Jiaxiang Bai 1 , Huaiyu Wang 2 , Hao Chen 1 , Gaoran Ge 1 , Miao Wang 3 , Ang Gao 2 , Liping Tong 4 , Yaozeng Xu 1 , Huiling Yang 1 , Guoqing Pan 3 , Paul K Chu 5 , Dechun Geng 6
Affiliation  

Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption and impair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. In addition, the peptide coating increases the bone-implant contact (BIC) by nearly 3 times resulting in suppressed osteoclastogenesis and promoted osteogenesis by inhibiting the nuclear factor kappa-B (NF-κB) signalling pathway. Our findings indicate that biomimetic peptides with osteoimmunomodulatory bioactivity can be incorporated into Ti-based prostheses to facilitate bone regeneration in patients with chronic inflammatory diseases.



中文翻译:

具有贻贝附着力和骨免疫调节功能的仿生成骨肽,可改善慢性炎症下的界面骨整合。

系统性慢性炎症患者的骨内假体植入后通常会导致骨整合不良,这主要是由于促炎细胞因子的增加导致骨骼吸收并损害了骨形成。在这项工作中,设计了肽涂层植入物,以在假体周围创建有益的骨免疫微环境,从而促进界面成骨。通过利用自发性和稳定的配位化学,钛基植入物被贻贝启发肽包覆,以通过上调巨噬细胞的M2表型减轻脂多糖(LPS)诱导的炎症。此外,肽涂层将骨与植入物的接触(BIC)增加了近3倍,从而通过抑制核因子κB(NF-κB)信号传导途径抑制了破骨细胞并促进了成骨作用。我们的研究结果表明,具有骨免疫调节生物活性的仿生肽可以掺入基于Ti的假体中,以促进慢性炎症性疾病患者的骨再生。

更新日期:2020-06-18
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