Iron catalysts with N-ligands for carbene transfer of diazo reagents.,Chemical Society Reviews

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Iron catalysts with N-ligands for carbene transfer of diazo reagents.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-06-12 , DOI: 10.1039/d0cs00221f
Caterina Damiano ₁ , Paolo Sonzini ₁ , Emma Gallo ₁

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Transition-metal-catalyzed carbene transfer reactions, involving diazo compounds and their precursors, are powerful tools for creating new C–C bonds. Depending on the involved catalytic system, the carbene insertion can efficiently be driven towards a specific functional group for the synthesis of a wide portfolio of fine chemicals. The present report is focused on the catalytic activity of iron catalysts in promoting alkene cyclopropanations, C–H and X–H (X = N, O, S, Se, Si, Sn, Ge) functionalizations. Porphyrin, porphyrinoid and non-heme iron complexes are discussed by analyzing experimental studies and theoretical calculations performed for proposing reaction mechanisms. The catalytic activity of artificial iron biocatalysts is also briefly reported in order to underline the similarities and differences between reaction mechanisms mediated by modified biocatalysts and synthetic catalysts. This review summarizes the achievements made in this field since 2006.

中文翻译：

具有N配体的铁催化剂，用于重氮试剂的卡宾转移。

涉及重氮化合物及其前体的过渡金属催化的卡宾转移反应是产生新的C-C键的有力工具。取决于所涉及的催化系统，卡宾的插入可以有效地驱动向特定的官能团，以合成多种精细化学品。本报告的重点是铁催化剂在促进烯烃环丙烷化，CH和CH（X = N，O，S，Se，Si，Sn，Ge）官能化方面的催化活性。通过分析实验研究和提出反应机理的理论计算，讨论了卟啉，卟啉类和非血红素铁配合物。为了强调由改性生物催化剂和合成催化剂介导的反应机理之间的异同，还简要报道了人工铁生物催化剂的催化活性。这篇综述总结了自2006年以来在该领域取得的成就。

更新日期：2020-07-21

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