Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.

伊维菌素具有治疗一系列疾病的许多潜在作用，其抗菌、抗病毒和抗癌特性是一种神奇的药物。它对包括一些病毒在内的许多微生物非常有效。在这篇全面的系统评价中，总结了伊维菌素的抗病毒作用，包括过去 50 年的体外和体内研究。几项研究报告了伊维菌素对 RNA 病毒的抗病毒作用，例如寨卡病毒、登革热病毒、黄热病病毒、西尼罗河病毒、亨德拉病毒、纽卡斯尔病毒、委内瑞拉马脑炎、基孔肯雅病毒、塞姆利基森林病毒、辛德比斯病毒、甲型禽流感病毒、猪繁殖和呼吸综合征、人类免疫缺陷病毒1 型和严重急性呼吸系统综合症冠状病毒 2。此外，有一些研究表明伊维菌素对 DNA 病毒（如 1 型马疱疹病毒、BK 多瘤病毒、伪狂犬病、猪圆环病毒 2 和牛疱疹病毒 1）具有抗病毒作用。伊维菌素在多种生物学机制中发挥作用，因此它可以作为潜在的候选药物用于治疗多种病毒，包括 COVID-19 以及其他类型的正链单链 RNA 病毒。动物模型的体内研究揭示了伊维菌素的广泛抗病毒作用，然而，临床试验对于评估伊维菌素在临床环境中的潜在功效是必要的。因此，它可以作为治疗多种病毒的潜在候选药物，包括 COVID-19 以及其他类型的正链单链 RNA 病毒。动物模型的体内研究揭示了伊维菌素的广泛抗病毒作用，然而，临床试验对于评估伊维菌素在临床环境中的潜在功效是必要的。因此，它可以作为治疗多种病毒的潜在候选药物，包括 COVID-19 以及其他类型的正链单链 RNA 病毒。动物模型的体内研究揭示了伊维菌素的广泛抗病毒作用，然而，临床试验对于评估伊维菌素在临床环境中的潜在功效是必要的。