The Pew Charitable Trusts’ 2016 publication “A Scientific Roadmap for Antibiotic Discovery” provided a consensus approach to accelerating the discovery of novel antibiotics targeting Gram-negative pathogens. Since then, encouraging initiatives have launched to catalyze antibiotics discovery, particularly by improving knowledge sharing and making discovery efforts more efficient and effective. However, because the global pipeline remains insufficient to address current and future unmet needs, existing initiatives are not enough. Sustained public funding is critical, particularly as private funding continues to dwindle. And with public funding comes the responsibility of sharing what has been learned. Finally, a “precompetitive” R&D model in which the financial return on investment is not a primary driver warrants further consideration.

中文翻译：

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在发现迫切需要的抗生素的道路上：那么遥远而又遥远。

皮尤慈善信托基金会（Pew Charitable Trusts）在2016年出版的《抗生素发现的科学路线图》为加快发现针对革兰氏阴性病原体的新型抗生素提供了一种共识方法。从那时起，就启动了鼓励人们采取行动来催化抗生素发现的举措，特别是通过改善知识共享并提高发现工作的效率和效力。但是，由于全球渠道仍然不足以满足当前和未来未满足的需求，因此现有的举措还不够。持续的公共资金至关重要，尤其是在私人资金不断减少的情况下。随着公共资金的到来，有责任分享所学知识。最后，需要进一步考虑“竞争前”的研发模型，在该模型中，投资的财务回报不是主要驱动力。