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Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-06-11 , DOI: 10.1021/acschemneuro.0c00249 Abolfazl Torabi 1 , Esmaeil Mohammadbagheri 2 , Nader Akbari Dilmaghani 3 , Amir-Hossein Bayat 4 , Mobina Fathi 1 , Kimia Vakili 1 , Rafieh Alizadeh 5 , Omidvar Rezaeimirghaed 6 , Mohammadreza Hajiesmaeili 7 , Mahtab Ramezani 6 , Leila Simani 6 , Abbas Aliaghaei 1
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-06-11 , DOI: 10.1021/acschemneuro.0c00249 Abolfazl Torabi 1 , Esmaeil Mohammadbagheri 2 , Nader Akbari Dilmaghani 3 , Amir-Hossein Bayat 4 , Mobina Fathi 1 , Kimia Vakili 1 , Rafieh Alizadeh 5 , Omidvar Rezaeimirghaed 6 , Mohammadreza Hajiesmaeili 7 , Mahtab Ramezani 6 , Leila Simani 6 , Abbas Aliaghaei 1
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Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and interleukin-1-beta (IL-1β) were assessed using ELISA and compared between groups. Average TNF-α levels were significantly increased in the olfactory epithelium of the COVID-19 group compared to the control group (P < 0.05). However, no differences in IL-1β were seen between groups. Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium in patients with COVID-19. This suggests that direct inflammation of the olfactory epithelium could play a role in the acute olfactory loss described in many patients with COVID-19.
中文翻译：
嗅觉粘膜中的促炎细胞因子导致 COVID-19 诱发的嗅觉丧失。
研究发现，2019 年新型冠状病毒病 (COVID-19) 患者的嗅觉障碍发生率有所增加。然而，导致嗅觉丧失的机制尚不清楚。本研究的主要目的是探讨 COVID-19 患者嗅觉上皮中局部促炎细胞因子的水平。对确诊的 COVID-19 患者以及未感染的对照患者进行嗅上皮活检。使用 ELISA 评估肿瘤坏死因子 α (TNF-α) 和白细胞介素 1-β (IL-1β) 的水平并进行组间比较。与对照组相比，COVID-19组嗅觉上皮的平均TNF-α水平显着升高（P < 0.05）。然而，各组之间的 IL-1β 没有发现差异。在 COVID-19 患者的嗅觉上皮中发现促炎细胞因子 TNF-α 水平升高。这表明嗅觉上皮的直接炎症可能在许多 COVID-19 患者所描述的急性嗅觉丧失中发挥作用。
更新日期：2020-07-01
中文翻译：
嗅觉粘膜中的促炎细胞因子导致 COVID-19 诱发的嗅觉丧失。
研究发现，2019 年新型冠状病毒病 (COVID-19) 患者的嗅觉障碍发生率有所增加。然而，导致嗅觉丧失的机制尚不清楚。本研究的主要目的是探讨 COVID-19 患者嗅觉上皮中局部促炎细胞因子的水平。对确诊的 COVID-19 患者以及未感染的对照患者进行嗅上皮活检。使用 ELISA 评估肿瘤坏死因子 α (TNF-α) 和白细胞介素 1-β (IL-1β) 的水平并进行组间比较。与对照组相比，COVID-19组嗅觉上皮的平均TNF-α水平显着升高（P < 0.05）。然而，各组之间的 IL-1β 没有发现差异。在 COVID-19 患者的嗅觉上皮中发现促炎细胞因子 TNF-α 水平升高。这表明嗅觉上皮的直接炎症可能在许多 COVID-19 患者所描述的急性嗅觉丧失中发挥作用。
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