Zinc-Calcium-Fluoride Bioglass-Based Innovative Multifunctional Dental Adhesive with Thick Adhesive Resin Film Thickness.,ACS Applied Materials & Interfaces

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Zinc-Calcium-Fluoride Bioglass-Based Innovative Multifunctional Dental Adhesive with Thick Adhesive Resin Film Thickness.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-06-12 , DOI: 10.1021/acsami.0c06865
Chenmin Yao _{1,

2} , Mohammed H Ahmed _{1,

3} , Xin Li ₁ , Ivana Nedeljkovic _{1,

4} , Jennifer Vandooren ₅ , Ben Mercelis ₁ , Fei Zhang _{1,

6} , Kirsten L Van Landuyt ₁ , Cui Huang ₂ , Bart Van Meerbeek ₁

Affiliation

Apart from producing high bond strength to tooth enamel and dentin, a dental adhesive with biotherapeutic potential is clinically desirable, aiming to further improve tooth restoration longevity. In this laboratory study, an experimental two-step universal adhesive, referred to as Exp_2UA, applicable in both the etch-and-rinse (E&R) and self-etch (SE) modes and combining a primer, containing 10-methacryloyloxydecyldihydrogen phosphate as a functional monomer with chemical binding potential to hydroxyapatite, with a bioglass-containing hydrophobic adhesive resin, was multifactorially investigated. In addition to primary property assessment, including measurement of bond strength, water sorption, solubility, and polymerization efficiency, the resultant adhesive–dentin interface was characterized by transmission electron microscopy (TEM), the filler composition was analyzed by energy-dispersive X-ray spectroscopy, and the bioactive potential of the adhesive was estimated by measuring the long-term ion release and assessing its antienzymatic and antibacterial potential. Four representative commercial adhesives were used as reference/controls. Application in both the E&R and SE modes resulted in a durable bonding performance to dentin, as evidenced by favorable 1 year aged bond strength data and a tight interfacial ultrastructure that, as examined by TEM, remained ultramorphologically unaltered upon 1 year of water storage aging. TEM revealed a 20 μm thick hydrophobic adhesive layer with a homogeneous bioglass filler distribution. Adequate polymerization conversion resulted in extremely low water sorption and solubility. In situ zymography revealed reduced endogenous proteolytic activity, while Streptococcus mutans biofilm formation was inhibited. In conclusion, the three-/two-step E&R/SE Exp_2UA combines the high bonding potential and bond degradation resistance with long-term ion release, rendering the adhesive antienzymatic and antibacterial potential.

中文翻译：

基于锌-氟化钙生物玻璃的创新型多功能牙科用胶粘剂，具有较厚的树脂膜厚度。

除了产生对牙釉质和牙本质的高粘结强度之外，具有生物治疗潜力的牙科用胶粘剂在临床上是理想的，目的是进一步提高牙齿修复的寿命。在本实验室研究中，一种实验性两步通用粘合剂，称为Exp_2UA，适用于蚀刻和冲洗（E＆R）和自蚀刻（SE）模式，并结合了底漆，其中包含10-甲基丙烯酰氧基癸基二氢磷酸酯用含生物玻璃的疏水性粘合树脂对具有与羟基磷灰石化学结合潜力的功能性单体进行了多方面研究。除了主要的性能评估（包括粘合强度，吸水率，溶解度和聚合效率的测量）外，所得的粘合剂－牙本质界面还采用透射电子显微镜（TEM）进行表征，通过能量色散X射线光谱法分析填料的组成，并通过测量长期的离子释放并评估其抗酶和抗菌能力来评估粘合剂的生物活性潜力。四种代表性的商业粘合剂用作参考/对照。在E＆R和SE模式下的应用均产生了对牙本质的持久粘合性能，这通过良好的1年老化粘合强度数据和紧密的界面超微结构得以证明（如TEM所观察到的那样），在贮水老化1年后，其形态学仍保持不变。TEM显示出20μm厚的疏水性粘合剂层，具有均匀的生物玻璃填料分布。足够的聚合转化率导致极低的吸水率和溶解度。变形链球菌生物膜形成受到抑制。总之，三步/两步E＆R / SE Exp_2UA结合了高键电势和耐键降解性以及长期释放离子的特性，使胶粘剂具有抗酶和抗菌能力。

更新日期：2020-07-08

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