The choice of nanocarriers is crucial to fabricate ideal therapeutic nanoplatform in the treatment of cancer. Considering the advantages brought by the two-dimensional (2D) materials with atomic thickness in drug loading and cellular uptake, herein, novel 2D biodegradable mesoporous organosilica nanosheets (MONSs) are presented, and their application in chemotherapy/mild thermotherapy of cancer is studied by loading chemotherapy drug doxorubicin (DOX) and conjugating ultrasmall CuS nanoparticles. It is found that the loading of DOX in MONSs is as high as 859 μg/mg due to their large surface area and intermediate void structure. The release of DOX from MONSs is intelligently controlled by pH value, glutathione (GSH) concentration, and laser irradiation. Excitingly, in comparison with traditional spherical mesoporous organosilica nanoparticles, as-prepared MONSs not only show more rapid degradation but also exhibit faster internalization and higher cellular uptake efficiency due to their larger aspect ratios and unique cellular internalization approach of 2D materials. A mild thermotherapy induced by ultrasmall CuS nanoparticles can further promote the cellular uptake and improve chemotherapy efficacy. The in vitro and in vivo experimental results reveal that the theranostic nanoplatform based on degradable MONSs has excellent biocompatibility and anticancer effects. Therefore, MONSs are expected to be a competitive alternative to existing silica-based nanomaterials in antitumor treatment.

中文翻译：

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用于癌症化学疗法/温和热疗法的可生物降解的介孔有机硅纳米片：快速内在化，高细胞摄取和高载药量。

纳米载体的选择对于制造治疗癌症的理想治疗性纳米平台至关重要。考虑到具有原子厚度的二维（2D）材料在药物负载和细胞摄取方面带来的优势，本文提出了新型的2D可生物降解的介孔有机硅纳米片（MONS），并研究了其在癌症化学疗法/温和热疗法中的应用加载化疗药物阿霉素（DOX）并结合超小CuS纳米颗粒。发现由于其大的表面积和中间的空隙结构，MONS中DOX的负载量高达859μg/ mg。从pH值，谷胱甘肽（GSH）浓度和激光照射可智能地控制MONS中DOX的释放。令人兴奋的是，与传统的球形中孔有机二氧化硅纳米粒子相比，制备的MONS不仅显示出更快的降解速度，而且由于其更大的纵横比和2D材料独特的细胞内在化方法，因此显示出更快的内在化和更高的细胞摄取效率。由超小型CuS纳米颗粒诱导的温和热疗可以进一步促进细胞吸收并改善化疗效果。的体外和体内实验结果表明，基于可降解MONSs的治疗药物纳米平台具有优异的生物相容性和抗癌作用。因此，在抗肿瘤治疗中，MONS有望替代现有的二氧化硅基纳米材料。