ABSTRACT

Many traditional plants have been used to fight life-threatening diseases such as diabetes, atherosclerosis and cancer. These plants have been shown to possess antioxidant activities, decrease the diabetes nuisance. The effect of 250 mg/kg b.wt of polyherbal drug (PHD) was investigated on high-fat diet-induced diabetic rats and impact of PHD administration was observed. The blood biochemical parameters such as glucose, insulin, hemoglobin, HbA1c, lipid profile and plasma antioxidants were evaluated. The increased levels of blood glucose, cholesterol, triglycerides and low-density lipoprotein cholesterol were noticed. In contrast, the levels of insulin and HDL-cholesterol were diminished. The oral administration of PHD showed a decrease in glucose level, cholesterol, triglycerides and LDL-cholesterol, whereas an increase in insulin level and HDL-cholesterol were recorded. What’s more, the antioxidant enzymes in diabetic control rats showed significantly decreased activities of SOD, catalase, glutathione peroxide activities and reduced glutathione (GSH) compared to treated diabetic rats and the extent of LPO. These results showed that our formulated PHDs have possessed antioxidant potential. The effect produced by the PHD on various parameters was comparable to that of Metformin – a standard anti-diabetic drug.

摘要

许多传统植物已被用来抵抗威胁生命的疾病，例如糖尿病，动脉粥样硬化和癌症。这些植物已显示具有抗氧化活性，可减少糖尿病的滋扰。研究了250 mg / kg b.wt的多草药药物（PHD）对高脂饮食诱导的糖尿病大鼠的作用，并观察到PHD施用的影响。评估了血液生化参数，例如葡萄糖，胰岛素，血红蛋白，HbA1c，脂质分布和血浆抗氧化剂。注意到血糖，胆固醇，甘油三酸酯和低密度脂蛋白胆固醇水平升高。相反，胰岛素和HDL-胆固醇的水平降低。口服PHD显示血糖，胆固醇，甘油三酸酯和LDL-胆固醇下降，而胰岛素水平和HDL-胆固醇升高。而且，与治疗的糖尿病大鼠和LPO的程度相比，糖尿病对照大鼠中的抗氧化酶显示出SOD，过氧化氢酶，谷胱甘肽过氧化物活性显着降低，谷胱甘肽（GSH）降低。这些结果表明，我们配制的PHD具有抗氧化潜力。PHD在各种参数上产生的效果与标准抗糖尿病药物二甲双胍相当。这些结果表明，我们配制的PHD具有抗氧化潜力。PHD在各种参数上产生的效果与标准抗糖尿病药物二甲双胍相当。这些结果表明，我们配制的PHD具有抗氧化潜力。PHD在各种参数上产生的效果与标准抗糖尿病药物二甲双胍相当。