Abstract

Pregnancy is a natural process that poses an immunological challenge because non-self fetus must be accepted. During the pregnancy period, the fetus as ‘allograft’ inherits maternal and also paternal antigens. For successful and term pregnancy, the fetus is tolerated and nurtured enjoying immune privileges that minimize the risk of being rejected by maternal immune system. Multiple mechanisms contribute to tolerate the semi-allogeneic fetus. Here, we summarize the recent progresses on how the maternal immune system actively collaborates to maintain the immune balance and maternal-fetal tolerance.

中文翻译：

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母胎界面的妊娠免疫耐受。

摘要

怀孕是一个自然过程，会带来免疫学挑战，因为必须接受非自身胎儿。在怀孕期间，作为“同种异体移植物”的胎儿继承了母本和父本的抗原。为了成功和足月妊娠，胎儿被容忍和培育，享受免疫特权，最大限度地减少被母体免疫系统排斥的风险。多种机制有助于耐受半同种异体胎儿。在这里，我们总结了母体免疫系统如何积极协作以维持免疫平衡和母胎耐受的最新进展。