Frailty, in elderly people, represents multiple deficiencies in different organs and is characterized by decreased physiological reserves and greater vulnerability to stressors. Bedridden elderly, with cardiovascular disease (CVD), have a worse prognosis than non-bedridden patients. Heat-shock proteins (HSPs) are molecular chaperones that under physiological conditions facilitate the transport, folding and assembly of proteins. Serum HSP 60-kDa concentrations and their antibodies are increased, in response to non-physiological conditions, suggesting the involvement of HSPs and their antibodies in the development of CVD. The aim of this work was to evaluate heat shock protein 60 and anti-HSP60 antibody levels, associated with a risk factor for cardiovascular disease, in bedridden elderly patients. Clinical, analytical and cross-sectional analyses were performed with 57 elderly (>65 years). HSP60 and anti-HSP60 plasma levels were measured by ELISA. Bivariate analysis using a linear regression model adjusted for risk factors used Framingham Score. Among the 57 elderly, with an average age of 69.89 years, 39% are bedridden; 26% with pre-existing cardiovascular disease and 44% are dyslipidemic. The relationship of risk factors in the Framingham Score was positive for the anti-HSP60 antibody (p = 0.042) measurement. Our data show a positive correlation among the elevation of the Framingham score and the profile of anti-HSP60 antibodies. These results suggest a greater immune activation that is associated with cardiovascular risk and bedridden fragility.

老年人的虚弱代表着不同器官的多种缺陷，其特点是生理储备减少，对压力源的抵抗力更大。卧床不起的患有心血管疾病（CVD）的老年人比未卧床的患者预后更差。热休克蛋白（HSP）是分子伴侣，在生理条件下可促进蛋白的运输，折叠和组装。响应非生理条件，血清HSP 60-kDa浓度及其抗体增加，提示HSP及其抗体参与了CVD的发展。这项工作的目的是评估卧床不起的老年患者的热休克蛋白60和抗HSP60抗体水平，这些水平与心血管疾病的危险因素有关。临床，对57名老年人（> 65岁）进行了分析和横断面分析。通过ELISA测量HSP60和抗HSP60血浆水平。使用针对风险因素进行调整的线性回归模型进行的双变量分析使用Framingham评分。在平均年龄为69.89岁的57位老年人中，有39％卧床不起。已有26％的人患有心血管疾病，另有44％的人患有血脂异常。Framingham评分中的危险因素与抗HSP60抗体呈阳性（p= 0.042）测量。我们的数据显示Framingham评分的升高与抗HSP60抗体的分布呈正相关。这些结果表明与心血管疾病风险和卧床不起的脆弱性有关的更大的免疫激活。