Resveratrol Alleviates Endoplasmic Reticulum Stress-Associated Hepatic Steatosis and Injury in Mice Challenged with Tunicamycin.,Molecular Nutrition & Food Research

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Resveratrol Alleviates Endoplasmic Reticulum Stress-Associated Hepatic Steatosis and Injury in Mice Challenged with Tunicamycin.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-28 , DOI: 10.1002/mnfr.202000105
Yanan Chen ₁ , Hao Zhang ₁ , Yueping Chen ₁ , Yuying Zhang ₁ , Mingming Shen ₁ , Peilu Jia ₁ , Shuli Ji ₁ , Tian Wang ₁

Affiliation

Endoplasmic reticulum (ER) stress is widely recognized as a critical factor linked to lipid metabolic disorders in nonalcoholic fatty liver disease. However, its pathogenesis remains elusive, and therapeutic options are limited. This study investigates the potential of resveratrol (RSV) to alleviate hepatic steatosis and injury in a tunicamycin (TM)‐induced murine ER stress model and provides detailed evidence.

中文翻译：

白藜芦醇缓解了与衣霉素相互作用的小鼠的内质网应激相关的肝脂肪变性和损伤。

内质网（ER）压力被广泛认为是与非酒精性脂肪肝疾病中脂质代谢异常相关的关键因素。然而，其发病机理仍然难以捉摸，并且治疗选择受到限制。这项研究调查了白藜芦醇（RSV）缓解由衣霉素（TM）诱导的鼠ER应激模型中的肝脂肪变性和损伤的潜力，并提供了详细的证据。

更新日期：2020-06-28

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