Caudate nuclei volume alterations and cognition and mood dysfunctions in adolescents with single ventricle heart disease.,Journal of Neuroscience Research

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Caudate nuclei volume alterations and cognition and mood dysfunctions in adolescents with single ventricle heart disease.
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-06-12 , DOI: 10.1002/jnr.24667
Sarah Noorani ₁ , Bhaswati Roy ₁ , Ashish K Sahib ₁ , Cristina Cabrera-Mino ₂ , Nancy J Halnon ₃ , Mary A Woo ₂ , Alan B Lewis ₄ , Nancy A Pike ₂ , Rajesh Kumar _{1,

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Affiliation

Adolescents with single ventricle heart disease (SVHD) exhibit mood and cognitive deficits, which may result from injury to the basal ganglia structures, including the caudate nuclei. However, the integrity of the caudate in SVHD adolescents is unclear. Our aim was to examine the global and regional caudate volumes, and evaluate the relationships between caudate volumes and cognitive and mood scores in SVHD and healthy adolescents. We acquired two high‐resolution T1‐weighted images from 23 SVHD and 37 controls using a 3.0‐Tesla MRI scanner, as well as assessed mood (Patient Health Questionnaire‐9 [PHQ‐9]; Beck Anxiety Inventory [BAI]) and cognition (Montreal Cognitive Assessment [MoCA]; Wide Range Assessment of Memory and Learning–2; General Memory Index [GMI]) functions. Both left and right caudate nuclei were outlined, which were then used to calculate and compare volumes between groups using ANCOVA (covariates: age, gender, and head‐size), as well as perform 3D surface morphometry. Partial correlations (covariates: age, gender, and head‐size) were used to examine associations between caudate volumes, cognition, and mood scores in SVHD and controls. SVHD subjects showed significantly higher PHQ‐9 and BAI scores, indicating more depressive and anxiety symptoms, as well as reduced GMI scores, suggesting impaired cognition, compared to controls. SVHD patients showed significantly reduced caudate volumes (left, 3,198.8 ± 490.1 vs. 3,605.0 ± 480.4 mm³, p < 0.004; right, 3,162.1 ± 475.4 vs. 3,504.8 ± 465.9 mm³, p < 0.011) over controls, and changes were localized in the rostral, mid‐dorsolateral, and caudal areas. Significant negative correlations emerged between caudate volumes with PHQ‐9 and BAI scores and positive correlations with GMI and MoCA scores in SVHD and controls. SVHD adolescents show significantly reduced caudate volumes, especially in sites that have projections to regulate mood and cognition, which may result from developmental and/or hypoxia‐/ischemia‐induced processes.

中文翻译：

患有单心室心脏病的青少年的尾状核体积改变以及认知和情绪功能障碍。

患有单心室心脏病 (SVHD) 的青少年表现出情绪和认知缺陷，这可能是由于基底神经节结构（包括尾状核）受损所致。然而，SVHD 青少年尾状核的完整性尚不清楚。我们的目的是检查全球和区域尾状核体积，并评估尾状核体积与 SVHD 和健康青少年的认知和情绪评分之间的关系。我们使用 3.0-Tesla MRI 扫描仪从 23 名 SVHD 和 37 名对照中获取了两张高分辨率 T1 加权图像，并评估了情绪（患者健康问卷-9 [PHQ-9]；贝克焦虑量表 [BAI]）和认知（蒙特利尔认知评估 [MoCA]；记忆和学习的广泛评估 - 2；一般记忆指数 [GMI]）功能。左右尾状核都被勾勒出来，然后使用 ANCOVA（协变量：年龄、性别和头部大小）计算和比较组间的体积，以及执行 3D 表面形态测量。偏相关（协变量：年龄、性别和头部大小）用于检查 SVHD 和对照组的尾状核体积、认知和情绪评分之间的关联。与对照组相比，SVHD 受试者的 PHQ-9 和 BAI 评分显着更高，表明更多的抑郁和焦虑症状，以及 GMI 评分降低，表明认知受损。SVHD 患者尾状核体积显着减少（左，3,198.8 ± 490.1 对 3,605.0 ± 480.4 mm 和头部大小）用于检查 SVHD 和对照组的尾状核体积、认知和情绪评分之间的关联。与对照组相比，SVHD 受试者的 PHQ-9 和 BAI 评分显着更高，表明更多的抑郁和焦虑症状，以及 GMI 评分降低，表明认知受损。SVHD 患者尾状核体积显着减少（左，3,198.8 ± 490.1 对 3,605.0 ± 480.4 mm 和头部大小）用于检查 SVHD 和对照组的尾状核体积、认知和情绪评分之间的关联。与对照组相比，SVHD 受试者的 PHQ-9 和 BAI 评分显着更高，表明更多的抑郁和焦虑症状，以及 GMI 评分降低，表明认知受损。SVHD 患者尾状核体积显着减少（左，3,198.8 ± 490.1 对 3,605.0 ± 480.4 mm³ , p < 0.004; 对，3,162.1 ± 475.4 vs. 3,504.8 ± 465.9 mm ³ , p < 0.011) 高于对照组，变化位于头侧、背外侧和尾侧区域。尾状核体积与 PHQ-9 和 BAI 评分呈显着负相关，与 SVHD 和对照组的 GMI 和 MoCA 评分呈正相关。SVHD 青少年的尾状核体积显着减少，特别是在具有调节情绪和认知的预测的部位，这可能是发育和/或缺氧/缺血诱导过程的结果。

更新日期：2020-06-12

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