Colon cancer is one of the most common human malignancies, and chemotherapy cannot yet prevent recurrence in all patients. Essential oils are phytocomplexes with antiproliferative properties. In this study we elucidated the antiproliferative properties and the effect on cell cycle progression of sicilian Salvia officinalis essential oil and its three main compounds on three human colon cancer cell lines. The essential oil was extracted by hydrodistillation and analysed by gas chromatography. Cell proliferation was evaluated by MTT assay, and the cell cycle distribution was determined by flow cytometry. Thirty-four compounds were identified in the tested essential oil. Thirty-four compounds were identified in the tested essential oil. Growth inhibition was observed after 72 h, with an impact on cell cycle progression and no effect on the viability of normal colonic epithelial cells. The study shows that Salvia officinalis essential oil and its three main components have an in vitro antiproliferative effect on colon cancer cells.

中文翻译：

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丹参精油及其三种主要成分在人结肠癌细胞系中诱导的抗增殖作用和细胞周期改变。

结肠癌是最常见的人类恶性肿瘤之一，化疗尚不能预防所有患者的复发。精油是具有抗增殖特性的植物复合物。在这项研究中，我们阐明了西西里丹参精油及其三种主要化合物对三种人类结肠癌细胞系的抗增殖特性和对细胞周期进程的影响。精油通过水蒸馏提取并通过气相色谱分析。MTT法评价细胞增殖，流式细胞术测定细胞周期分布。在测试的精油中鉴定出 34 种化合物。在测试的精油中鉴定出 34 种化合物。72 小时后观察到生长抑制，对细胞周期进程有影响，对正常结肠上皮细胞的活力没有影响。研究表明，丹参精油及其三种主要成分对结肠癌细胞具有体外抗增殖作用。