Ten undescribed cembrane-type diterpenes boscartins AL-AU, as well as five known analogues were isolated from Boswellia sacra Flueck. The relative configurations of these boscartins were established by extensive spectroscopic analysis of NMR spectra, IR and MS. The absolute configurations of boscartin AL, boscartin AN and isoincensole oxide were unequivocally assigned by single crystal X-ray diffraction. Meanwhile, the absolute configurations of boscartin AM, boscartin AP and boscartin AQ were determined by an empirical in situ formed Rh-complex ECD method. Biological evaluations showed that four compounds exhibited obvious hepatoprotective activities against paracetamol-induced HepG2 cell damage at 10 μM. Regarding neuroprotective activity, some isolates displayed moderate to evident protective effects against glutamate-induced toxicity in primary cultured fetal rat cortical neurons or oxygen-glucose deprivation toxicity in SK-N-SH Cells at 10 μM.

中文翻译：

---

来自乳香树胶脂的 10 种未描述的 cembrane 型二萜及其生物活性

从 Boswellia sacra Flueck 中分离出 10 种未描述的 cembrane 型双萜 boscartins AL-AU，以及五种已知的类似物。这些 boscartins 的相对构型是通过广泛的 NMR 光谱、IR 和 MS 光谱分析建立的。单晶 X 射线衍射明确指定了 boscartin AL、boscartin AN 和异香精油的绝对构型。同时，boscartin AM、boscartin AP和boscartin AQ的绝对构型是通过经验原位形成的Rh复合ECD方法确定的。生物学评估表明，四种化合物在 10 μM 时对扑热息痛诱导的 HepG2 细胞损伤表现出明显的保肝活性。关于神经保护活性，