Abstract The resistant biological properties of natural secreted antibodies have been proved across a spectrum of diseases, including cancers, infections, and immune disorders. At the interface of nanotechnology and biotechnology, the genetically engineered membrane nanovesicles (MVs) with specific cavity structure and ideal surface protein anchoring have presented excellent performance in functional moieties delivery with high physicochemical stability and biocompatibility. Furthermore, vesicular antibodies that express functional antibodies on MVs via genetic engineering methods could successfully bridge the superiority of functional antibodies and natural MVs. It would be a portfolio strategy to incorporate molecule-targeted and immune-targeted therapies into an efficient regimen, just like “guided missiles”.

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用于免疫治疗的囊泡抗体：纳米技术和生物技术的蓬勃发展

摘要 天然分泌抗体的抗性生物学特性已在一系列疾病中得到证实，包括癌症、感染和免疫紊乱。在纳米技术和生物技术的交界处，具有特定腔结构和理想表面蛋白质锚定的基因工程膜纳米囊泡（MVs）在功能部分传递方面表现出优异的性能，具有高物理化学稳定性和生物相容性。此外，通过基因工程方法在 MV 上表达功能性抗体的囊泡抗体可以成功地将功能性抗体和天然 MV 的优势结合起来。将分子靶向和免疫靶向疗法纳入有效的治疗方案将是一种投资组合策略，就像“导弹”一样。