Generally, all hydrogenotrophic methanogens can use the most important greenhouse gases (CO₂ and CO) as sole carbon sources for energetic metabolism and biosynthesis of methane. Amongst them, Methanothermobacter thermautotrophicus strain ΔH is a potential microorganism for the bioconversion of CO₂ with H₂ and/or CO to methane in thermophilic anaerobic reactors. The present article has comprehensively summarized the recent genomic, metabolic, and transcriptional regulatory aspects of this microorganism. Extensive experimental studies of metabolic and transcription regulatory systems of this microorganism have been evidenced for its hydrogenotrophic methanogenic activity in diverse environments. Genome-scale metabolic models of several mesophilic methanogens have been developed for integrative analysis of their cellular and metabolic processes during methanogenesis. Moreover, these models have been bestowed a new avenue for the genome annotation, metabolic refinement, and model-driven systems engineering. Bioprocess operational parameters have been acquainted for a better understanding of the metabolic competence of this organism for the bioconversion of CO₂ with external H₂ and/or CO to CH₄ in the lab-scale reactors. It allows us to exploit this organism to capture flue gas carbon in the future if systems biological characteristics of this organism are unraveled to date. Hence, the systems biology perspective of this organism would expedite our acquaintance in the ‘Power-to-Methane Gas’ applications as well as biogas upgrading processes.

通常，所有氢营养型产甲烷菌都可以使用最重要的温室气体（CO ₂和CO）作为甲烷的能量代谢和生物合成的唯一碳源。其中，甲烷嗜热杆菌嗜热自养菌株ΔH是CO ₂与H ₂生物转化的潜在微生物。和/或在高温厌氧反应器中将CO转化为甲烷。本文已全面总结了该微生物的最新基因组，代谢和转录调控方面。已经证明了该微生物的代谢和转录调节系统的广泛实验研究，证明了其在各种环境中的氢营养甲烷化活性。已经开发了几种嗜温产甲烷菌的基因组规模的代谢模型，用于在产甲烷过程中对其细胞和代谢过程进行综合分析。而且，这些模型为基因组注释，代谢细化和模型驱动的系统工程提供了新途径。₂在实验室规模的反应器中带有外部H ₂和/或CO至CH ₄。如果迄今尚未阐明该生物的系统生物学特征，它将使我们能够在将来利用该生物捕获烟气中的碳。因此，这种生物的系统生物学观点将加快我们对“沼气发电”应用以及沼气升级过程的了解。